1990—2019年中国周围动脉疾病患病性别差异情况研究  

Analysis of Gender Differences in Peripheral Arterial Disease Prevalence from 1990 to 2019 in China

作　　者：刘林波[1] 廖智杰[1] 杨文凡 白丹丹 王冬梅[1] 施森 LIU Linbo;LIAO Zhijie;YANG Wenfan;BAI Dandan;WANG Dongmei;SHI Sen(Department of Vascular Surgery,the Third Hospital of Mianyang/Sichuan Mental Health Center,Mianyang 621000,China;Department of Vascular Surgery,the Affiliated Hospital of Southwest Medical University,Luzhou 646099,China)

机构地区：[1]四川省绵阳市第三人民医院、四川省精神卫生中心血管外科,621000 [2]西南医科大学附属医院血管外科,四川省泸州市646099

出　　处：《中国全科医学》2023年第35期4425-4432,4438,共9页Chinese General Practice

基　　金：四川省卫生健康委科研课题(18PJ488);四川省医学会(恒瑞)科研基金专项科研课题(2021HR65)。

摘　　要：背景周围动脉疾病(PAD)是心血管疾病中一种常见的、严重的疾病,易并发肢体缺血及心血管不良事件。PAD的患病有性别差异,而相关研究相对缺乏。充分认识中国PAD患病情况的性别差异对于公共卫生政策的制定至关重要。目的分析中国PAD患病情况中的性别差异及其原因,为制订有针对性的筛查和预防措施提供理论依据。方法通过2019年全球疾病负担(GBD)数据库提取中国男性和女性以及全球、日本、韩国和印度女性的PAD患病人数、患病率、年龄标化患病率、疾病负担可归因危险因素以及相应95%不确定区间(UI)。采用R语言进行本研究数据和可视化分析。采用Joinpoint软件分析1990—2019年中国男性和女性PAD患病率随时间变化的趋势,计算PAD患病率的年度变化百分比(APC)和平均年度变化百分比(AAPC)以及其95%可信区间(CI)。采用贝叶斯年龄-时期-队列(BAPC)模型预测2020—2035年PAD的患病人数和患病率。结果中国2019年PAD患病率例数男性为71.74×10万,女性为213.15×10万。与1990年比较,2019年PAD患病人数男性增加了154.22%,女性增加了181.27%。2019年日本、韩国、印度和全球女性PAD患病人数、患病率均较1990年升高,但年龄标化患病率均降低,1990年中国女性PAD年龄标化患病率分别为日本和韩国女性的57.80%和76.35%,2019年则分别为日本和韩国的1.10倍和1.33倍。中国男性PAD患病率1990年为462.40/10万,2019年为989.79/10万,增幅为114.05%,1990—2019年呈上升趋势。中国女性PAD的患病率1990年为1321.44/10万,2019年为3055.85/10万,增幅为131.25%,1990—2019年呈上升趋势。2019年中国女性PAD患病率是男性的3.09倍。中国男性PAD的年龄标化患病率1990年为731.02/10万,2019年为744.96/10万,增幅为1.91%,1990—1993年、1993—2005年呈上升趋势,2005—2019年呈下降趋势。中国女性PAD的年龄标化患病率1990年为1839.43/10万,2019年为2022.13/10万,增�Background Peripheral artery disease(PAD)is a common and serious cardiovascular disease,which is prone to complications of limb ischemia and adverse cardiovascular events.There is a gender difference in the prevalence of PAD,which has been relatively poorly studied.A full understanding of gender differences in prevalence of PAD in China is essential for public health policy development.Objective To analyze the gender differences in the prevalence of PAD in China and their causes,providing a theoretical basis for targeted screening and preventive measures.Methods The number of PAD cases,prevalence,age-standardized prevalence,attributable risk factors for disease burden,and corresponding 95%uncertainty intervals(UI)were extracted from the 2019 Global Burden of Disease(GBD)database for males and females in China and females in Japan,Korea,India and globally.R language was used to analyze the data and visualize the analysis of this study.Joinpoint software was used to analyze the trend of PAD prevalence in males and females in China over time from 1990 to 2019,and the annual percentage change(APC)and average annual percentage change(AAPC)of PAD prevalence and their 95%confidence intervals(CI)were calculated.A Bayesian age-period-cohort(BAPC)model was used to predict the number and prevalence of PAD in 2020—2035.Results The estimated prevalence of PAD in China in 2019 was 71.74×100000 for males and 213.15×100000 for females.Compared with 1990,the number of PAD cases in 2019 increased by 154.22%in males and 181.27%in females.In 2019,the number of cases and prevalence of PAD among males in Japan,Korea,India and globally were all higher than those in 1990,but the age-standardized prevalence was lower.In 1990,the age-standardized prevalence of PAD among women in China was 57.80%and 76.35%of those in Japan and Korea,1.10 times and 1.33 times of those in Japan and Korea in 2019.The prevalence of PAD in Chinese men was 462.40/100000 in 1990 and 989.79/100000 in 2019,with an increase of 114.05%,and showed an upward trend

关 键 词：周围动脉疾病 患病率 全球疾病负担 贝叶斯年龄-时期-队列模型 贝叶斯预测 

分 类 号：R543.5[医药卫生—心血管疾病] R195.4[医药卫生—内科学]