自体富血小板浓缩物在妇科领域中的应用研究进展  

Advances in the Application of Autologous Platelet Concentrate in the Field of Gynecology

作　　者：王小雪 毛乐乐 王子君 杨慕坤 白文佩 刁翯 WANG Xiaoxue;MAO Lele;WANG Zijun;YANG Mukun;BAI Wenpei;DIAO He(Department of Obstetrics and Gynecology,Peking University Ninth School of Clinical Medicine/Beijing Shijitan Hospital,Beijing100038,China;Department of Traditional Chinese Medicine,Tianjin Central Hospital of Gynecology Obstetrics,Tianjin 300199,China;Tianjin Key Laboratory of Human Development and Reproductive Regulation,Tianjin 300199,China)

机构地区：[1]北京大学第九临床医学院、北京世纪坛医院妇产科,北京市100038 [2]天津市中心妇产科医院中医科,300199 [3]天津市人类发育与生殖调控重点实验室,300199

出　　处：《中国全科医学》2023年第35期4472-4476,4482,共6页Chinese General Practice

基　　金：国家自然科学基金青年科学基金项目(82004409);北京市医院管理中心临床医学发展专项经费资助(ZYLX202112);首都医科大学附属北京世纪坛医院青年基金(2021-q21)。

摘　　要：自体富血小板浓缩物是通过抽取人体或动物血液经过离心获得的血小板浓缩物,主要包括第一代血小板浓缩物富血小板血浆(PRP)及第二代血小板浓缩物富血小板纤维蛋白(PRF)。因其促进伤口愈合及组织修复的作用,被广泛运用于口腔种植、骨缺损修复、烧伤整形等领域。近年来,自体富血小板浓缩物开始运用于改善卵巢功能、促进子宫内膜增生修复、治疗宫颈及外阴相关病变,并取得了显著疗效,但目前缺乏对PRP、PRF在妇科领域研究成果的有效整合。本文系统、全面地梳理了自体富血小板浓缩物的制备、生物学特性以及在妇科多种疾病中的应用,以期能为临床医生提供妇科相关疾病新的治疗思路,并为自体富血小板浓缩物研究应用的深入开展提供借鉴。Autologous platelet concentrate(APC)is a platelet concentrate obtained by centrifugation of human or animal blood,mainly includes first-generation platelet concentrate platelet-rich plasma(PRP)and second-generation platelet concentrate platelet-rich fibrin(PRF),which is widely applied in varies fields such as dental implants,bone defect repairing and burn plastic surgery because of its role in wound healing and tissue repair.In recent years,autologous platelet concentrate has been applied to improve ovarian function,promote the repair of endometrial hyperplasia,treat cervical and vulvo-related lesions,and has achieved significant efficacy.However,there is a lack of effective integration of PRP and PRF research results in the field of gynecology.This paper systematically and comprehensively review the preparation,biological properties and applications in various gynecological diseases,in order to provide clinicians with new treatment ideas for gynecological diseases and reference for the further application of APC.

关 键 词：妇科疾病 富血小板血浆 富血小板纤维蛋白 自体富血小板浓缩物 子宫内膜增生 卵巢疾病 综述 

分 类 号：R711[医药卫生—妇产科学]