二甲双胍抗衰老分子机制的研究进展  

Advances in molecular mechanisms of Metformin against aging

作　　者：王浩 宁晓暄 Wang Hao;Ning Xiaoxuan(Department of Geriatrics,The First Affiliated Hospital of Air Force Military Medical University,Xi'an 710032,China)

机构地区：[1]空军军医大学第一附属医院老年病科,西安710032

出　　处：《中华老年医学杂志》2023年第8期1001-1007,共7页Chinese Journal of Geriatrics

基　　金：国家自然科学基金(82270715)。

摘　　要：米糖尿病是老年人常见疾病。二甲双胍是使用最广泛的抗糖尿病药物,通过营养感应调控、维持蛋白质稳态、保护线粒体功能、改变细胞间通信、端粒保护等途径,表现出延缓衰老的特殊作用。研究结果显示,二甲双胍表现出抗衰老的潜力,为此有必要对二甲双胍抗衰老的分子机制及其研究进展进行分析总结。Diabetes is a prevalent disease among the elderly population.Among the antidiabetic drugs,Metformin is the most commonly used,and has been found to have unique anti-aging effects through nutritional sensing regulation,maintenance of protein homeostasis,protection of mitochondrial function,alteration of intercellular communication,and telomere protection,among other mechanisms.The results of studies have shown that Metformin has significant anti-aging potential,thereby necessitating a thorough analysis and summary of its molecular mechanism and research progress in this regard.

关 键 词：二甲双胍 衰老 分子生物学 行衔接蛋白质类 信号转导 线粒体 

分 类 号：R96[医药卫生—药理学]