Artificial Water Channel that Couples with Cell Protrusion Formation  

作　　者：Qi Xiao Ting Fan Yinglan Wang Zhan-Ting Li Jun-Li Hou Yunfeng Wang 

机构地区：[1]Department of Chemistry,Fudan University,Shanghai 200433 [2]ENT Institute and Otorhinolaryngology Department of Eye&ENT Hospital,Fudan University,Shanghai 200031

出　　处：《CCS Chemistry》2023年第8期1745-1752,共8页中国化学会会刊（英文）

基　　金：the National Natural Science Foundation of China(NSFC)(grant nos.21921003,82071043,and 21725202);the Science and Technology Commission of Shanghai Municipality(STCSM,grant nos.22JC1403700 and 22JC1403702)for financial support.

摘　　要：In natural systems,water transport across the cellular plasma membranes is mainly mediated by naturally occurring channel protein aquaporins(AQPs),which lead to a series of important physiological functions including cell migration.The construction of artificial analogs of the natural AQPs would generate a new strategy for treating AQP-related diseases.In this report,an artificial water channel has been developed from a unimolecular tubular molecule,which featured structural encapsulation of a single-file water wire composed of oppositely orientated dipolar water molecules.This AQP-like structure endowed the artificial channel in living cells with AQP-like water permeability and selectivity.Interestingly,the artificial channel coupled with cell protrusion formation by mediating water transmembrane transport,leading to cell shape change and migration acceleration.The artificial channel-facilitated cell migration showed application in enhancing in vivo healing of traumatic injury.

关 键 词：artificial water channel AQUAPORIN cell protrusion cell migration injury healing 

分 类 号：O62[理学—有机化学]