采用ICP-MS法测定塑料输液容器金属离子的溶出量  

Determination of dissolution of metal ions from plastic infusion containers by ICP-MS

作　　者：艾俊涛 刘园园 刘磅 罗洁 黄海萍 颜敏 Ai Juntao;Liu Yuanyuan;Liu Pang;Luo Jie;Huang Haiping;Yan Min(Hunan Provincial Drug Audit and Inspection Center,Changsha 410001,China;Hunan Testing Institute for Medical Devices,Changsha 410010,China)

机构地区：[1]湖南省药品审核查验中心,长沙410001 [2]湖南药品检验检测研究院,长沙410010

出　　处：《分析仪器》2023年第4期55-58,共4页Analytical Instrumentation

摘　　要：目的:利用电感耦合等离子体质谱(ICP?MS)建立能准确、快捷且重复性好的同时测定塑料输液容器中的铜(Cu)、铁(Fe)、镉(Cd)、铬(Cr)、铅(Pb)、锡(Sn)、钡(Ba)、铝(Al)、锑(Sb)、钛(Ti)、镁(Mg)、镍(Ni)、锌(Zn)、钼(Mo)、钴(Co)、钒(V)共16种金属离子的溶出量的方法。方法:样品经处理后加水200mL,121℃加热30min,取浸提液,采用电感耦合等离子体质谱法,选择锂(~6Li)、钪(~(45)Sc)、锗(~(74)Ge)、钇(~(89)Y)、铟(~(115)In)和铽(~(159)Tb)作为内标,同时测定16种离子的浓度。结果:16种金属离子在1~100μg·L~(-1)范围内线性关系良好(r=0.9992~1.0000),精密度(RSD)CV值均小于2.3%,加样回收率(n=6)为80.12%~105.15%。结论:本方法准确度高、重现性好,省时、高效,节约了测定时间,可用于同时测定塑料输液容器中16种金属离子溶出量。The concentrations of 16 metal ions in leaching solution of plastic infusion containers,including cuprum(Cu),ferrum(Fe),cadmium(Cd),chromium(Cr),plumbum(Pb),stannum(Sn),barium(Ba),aluminum(Al),stibium(Sb),titanium(Ti),magnesium(Mg),nickel(Ni),zinc(Zn),molybdenum(Mo),cobalt(Co),vanadium(V)Metal ions were simultaneously determined.Processed sample was dipped in 200mL water,and heated for 30 minutes at 120℃.Then the concentrations of the 16 ions in leaching solution were determined,using ICP-MS,optimizing the instrument parameters and selecting lithium(6Li),scandium(45Sc)、germanium(74Ge)、yttrium(89Y)、indium(115In)and terbium(159Tb)as internal standards of the 16 elements.The results showed that linear range of the 16 ions were 1—100μg·L-1(r=0.9992—1.0000),the relative standard deviation were below 2.3%.The recoveries of the 16 Metal ions(n=6)were 80.12%—105.15%.This method is accurate,reproducible,save time,and efficient.

关 键 词：电感耦合等离子体质谱 金属离子 塑料输液容器 

分 类 号：O657.63[理学—分析化学] TQ460.69[理学—化学]