滋肾丸及组方药物抗糖尿病研究进展  

Anti-diabetic Effect of Zishenwan and Its Herbal Components: A Review

作　　者：吴悠 亓智玮 刘铜华[1] 秦灵灵[1] 吴丽丽[1] WU You;QI Zhiwei;LIU Tonghua;QIN Lingling;WU Lili(Key Laboratory of Health Cultivation of the Ministry of Education,Key Laboratory of Health Cultivation of Beijing,Beijing University of Chinese Medicine,Beijing 100029,China;School of Life Science,Beijing University of Chinese Medicine,Beijing 102488,China)

机构地区：[1]北京中医药大学教育部中医养生学重点实验室,中医养生学北京市重点实验室,北京100029 [2]北京中医药大学生命科学学院,北京102488

出　　处：《中国实验方剂学杂志》2023年第17期212-220,共9页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：高等学校学科创新引智计划项目(B20055);科技部国家国际合作基地项目(2015B01022)。

摘　　要：滋肾丸又名通关丸,由知母、黄柏、肉桂3味中药配伍而成,被认为是清热泻火、滋阴化气的经典方剂,被用于治疗癃闭及肾痹等疾病。在近代,滋肾丸又演变为一个常用药对,用于治疗糖尿病(中医消渴病)表现为“下消”者。该文系统综述了滋肾丸的中医理论沿袭,并基于现代药理学研究,总结了既往对滋肾丸成分分析、滋肾丸改善糖尿病相关疾病和其3味组方成分的单味药与糖尿病治疗之间的相关研究,对其药物成分和3个组方药物治疗糖尿病的机制进行了总结论述。综述发现,滋肾丸可以通过抗炎、增强胰岛素敏感性、抑制肾小管上皮焦亡等机制改善糖尿病和糖尿病肾病。而滋肾丸中知母、黄柏、肉桂单味药及其含有的多种成分,包括芒果苷、知母皂苷、小檗碱、药根碱、肉桂酸、肉桂醛等,可通过多种机制如改善胰岛素靶器官的胰岛素抵抗、抑制炎症、抗氧化、调节脂代谢、刺激胰岛素分泌、调节肠道菌群等改善糖尿病、维持糖代谢稳态。该综述为后续滋肾丸干预糖尿病相关机制研究奠定理论基础和相关参考。Zishenwan,also known as Tongguanwan,is composed of three herbs:Anemarrhenae Rhizoma,Phellodendri Chinensis Cortex,and Cinnamomi Cortex,which thus is thought to be the representative formula to clear heat,purge fire,nourish Yin,and tonify Qi,and it is often used for treating anuresis and renal arthralgia.In recent years,this formula has become a commonly used combination of herbs and is used to treat diabetes(consumptive thirst disease)diagnosed with"lower consumption"syndrome.This article systematically reviewed the development of traditional Chinese medicine(TCM)theory for Zishenwan.Moreover,based on modern pharmacological research,the previous studies on the components of Zishenwan,the improvement of diabetes-related diseases by Zishenwan,and the relationship between the single herd of Zishenwan and the treatment of diabetes were summarized,and the chemical components and the mechanisms for treating diabetes by the three herbs were discussed.It is found that Zishenwan can alleviate diabetes and diabetic nephropathy by performing anti-inflammation,enhancing insulin sensitivity,and inhibiting pyroptosis of renal tubular epithelial cells.Three herbs in Zishenwan and several components of them,including mangiferin,timosaponins,berberine,jatrorrhizine,cinnamaldehyde,and cinnamic acid can ameliorate diabetes and maintain stable glycometabolism by a variety of mechanisms such as improving insulin resistance in insulin target tissues,suppressing inflammation,anti-oxidation,regulating lipid metabolism,enhancing insulin secretion,and regulating gut microbiota.This review provides a theoretical foundation and reference for subsequent studies on the mechanisms of the anti-diabetic effect of Zishenwan.

关 键 词：滋肾丸 糖尿病 机制 知母 黄柏 肉桂 

分 类 号：R2-0[医药卫生—中医学] R22R285.5R284R33