中医药靶向Notch信号通路防治糖尿病肾病肾脏纤维化研究进展  

Traditional Chinese Medicine in Prevention and Treatment of Renal Fibrosis in Diabetic Nephropathy by Targeting Notch Signaling Pathway:A Review

作　　者：王雨典 周荣 董凯旋 陈曦[1] 于小勇 WANG Yudian;ZHOU Rong;DONG Kaixuan;CHEN Xi;YU Xiaoyong(Shaanxi University of Chinese Medicine,Xianyang 712046,China;Shaanxi Provincial Hospital of Chinese Medicine,Xi'an 710003,China)

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]陕西省中医医院,西安710003

出　　处：《中国实验方剂学杂志》2023年第17期221-227,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(82174366);陕西省中医药管理局项目(2021-GJ-LC022)。

摘　　要：糖尿病肾病(DN)是世界范围内常见的慢性肾脏病(CKD)之一,也是导致终末期肾病(ESRD)的主要原因,已严重威胁且影响到全球人类的生活健康。目前认为,DN的发病是在机体持续高糖环境下,糖代谢紊乱、脂质代谢异常、氧化应激、炎症因子激活、自噬及细胞凋亡等诸多因素密切相关。肾脏纤维化是DN发展的重要病理特征和最终病理结果,对肾脏纤维化及时干预对于DN防治具有重要的临床和现实意义。因西医治疗DN的局限性,中医药干预DN肾脏纤维化的进程以其多成分、多效应、多靶点的协同作用有效延缓疾病进展,常被用作DN治疗的常规和潜在治疗方法。研究发现,Notch信号通路在机体发育和维持稳态的过程中起重要作用,Notch信号通路异常激活与DN发生相关,该信号通路的激活在肾脏纤维化进程起关键作用。文章综述了Notch信号通路在DN肾脏纤维化的调控机制,重点探讨了中药单体及中药复方靶向Notch信号通路与DN肾脏纤维化的关系,以期为中医药防治DN的新药研发、基础研究及临床应用提供一定理论依据。Diabetic nephropathy(DN)is one of the common chronic kidney diseases(CKD)worldwide and a major cause of end-stage renal disease(ESRD),seriously threatening and affecting the life and health of the global population.Currently,the pathogenesis of DN is considered to be closely related to factors such as glucose metabolism disorders,abnormal lipid metabolism,oxidative stress,activation of inflammatory factors,autophagy,and cell apoptosis in the continuous high-glucose environment of the body.Renal fibrosis is an important pathological feature and ultimate pathological outcome of DN.Timely intervention in renal fibrosis is of significant clinical and practical importance for the prevention and treatment of DN.Due to the limitations of western medicine in treating DN,traditional Chinese medicine(TCM)intervention in the process of renal fibrosis in DN has been widely used as a routine and potential treatment method due to its multi-component,multi-effect,and multi-target effects,effectively delaying the progression of the disease.It has been found that the Notch signaling pathway plays an important role in the development and maintenance of homeostasis in the body, and abnormal activation of the Notch signaling pathway is associated with DN. Activation of this signaling pathway plays a key role in the process of renal fibrosis. This article reviewed the regulatory mechanism of the Notch signaling pathway in renal fibrosis in DN, focusing on the relationship between targeting Notch signaling pathway by Chinese medicinal monomers and prescriptions and renal fibrosis in DN in order to provide a theoretical basis for the development of new drugs, basic research, and clinical application of TCM in the prevention and treatment of DN.

关 键 词：糖尿病肾病 肾脏纤维化 NOTCH 中医药 信号通路 综述 

分 类 号：R2-0[医药卫生—中医学] R22R285.5R284R33