参麦注射液心血管保护作用的研究进展  

Cardiovascular Protective Effect of Shenmai Injection: A Review

作　　者：黄小燕 付雪 邓意 雷思思 包崑 陈伯钧 HUANG Xiaoyan;FU Xue;DENG Yi;LEI Sisi;BAO Kun;CHEN Bojun(The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120,China)

机构地区：[1]广州中医药大学第二附属医院,广州510120

出　　处：《中国实验方剂学杂志》2023年第17期237-247,共11页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(82004268,82074342,82260911,81960854);广州市科技局基础与应用基础研究项目(202102020529);江西省自然科学基金面上项目(20202BAB206070,20192BAB205099);广东省中医药管理局项目(20212089,20233021);2022年广东省中医院博士后专项科研课题(10814);中国博士后科学基金面上项目(2023M730810);广东省中医院中医药科学研究专项课题(YN2019QJ01);2020广东省科技创新战略专项资金(粤港澳联合实验室)项目(2020B1212030006)

摘　　要：随着人们生活水平的日益提高及老龄化的加剧,心血管疾病发病率急剧上升,己成为人类死亡病因最高的头号“杀手”,其防治仍然面临严峻的形势。参麦注射液是一种纯中药制剂,因其辨证施治的个性化优势且疗效肯定,在心血管疾病的防治中被广泛运用;同时,其药理作用及相关机制也日益明朗。现代研究表明,参麦注射液可通过减轻心肌炎症反应、减轻氧化应激反应、抑制心肌细胞凋亡、改善心肌缺血再灌注后微循环功能障碍、保护线粒体结构和功能、抑制心室重构、减轻药物心脏毒性及抗病毒等作用产生心肌保护作用;还可通过舒缩血管、保护内皮细胞及促进血管新生等作用产生心血管保护作用;另外,参麦注射液可降低血液黏度及血脂,具有改善血流流变学的作用。未来,需要更多的临床试验及基础研究阐明其疗效及作用靶点,以进一步证实其临床应用的有效性及安全性。With the improvement of people's living standards and the increasing aging population,the incidence of cardiovascular diseases has sharply risen,making it the leading cause of death and a major"killer"for humans.The prevention and treatment of cardiovascular diseases still face severe challenges.Shenmai injection(SMI),a Chinese medicinal preparation,is widely used in the prevention and treatment of cardiovascular diseases because of its individualized advantages in syndrome differentiation and definite efficacy.Meanwhile,its pharmacological effects and related mechanism are becoming increasingly clear.Modern research shows that SMI can exert cardioprotective effects by reducing myocardial inflammatory response,alleviating oxidative stress,inhibiting myocardial cell apoptosis,improving microcirculatory dysfunction after myocardial ischemia-reperfusion,protecting mitochondrial structure and function,inhibiting ventricular remodeling,reducing drug-induced cardiotoxicity,and possessing antiviral properties.Additionally,it can produce cardiovascular protection by relaxing blood vessels,protecting endothelial cells,and promoting angiogenesis.Furthermore,SMI can lower blood viscosity and lipid levels,thus improving blood rheology.In the future,more clinical trials and basic research are needed to clarify its therapeutic efficacy and target mechanism to further confirm the effectiveness and safety of its clinical application.

关 键 词：参麦注射液 心血管保护 心肌作用 心血管作用 血液流变 

分 类 号：R2-0[医药卫生—中医学] R22R285.5R284R2-031R586