巨噬细胞葡萄糖代谢重编程在结核肉芽肿形成中的作用  

Effects of macrophage glycolytic reprogramming on tuberculosis granuloma formation

作　　者：金琳羚 何梦钰 周宏 解卫平 孔辉 Jin Linling;He Mengyu;Zhou Hong;Xie Weiping;Kong Hui(Department of Pulmonary and Critical Care Medicine,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院呼吸与危重症医学科,南京210029

出　　处：《中华结核和呼吸杂志》2023年第8期834-838,共5页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：国家自然科学基金(81870054,82000061)。

摘　　要：结核病的典型病理特征为肉芽肿形成,结核分枝杆菌感染是其主要病因。目前肉芽肿形成的机制尚不完全清楚,研究显示免疫代谢机制在其中发挥了重要作用。本文从巨噬细胞葡萄糖代谢重编程角度总结近年来结核肉芽肿形成机制的研究进展,以期寻找早期诊断新方法,并为发展基于免疫代谢调控的药物治疗提供新思路。The formation of granulomatous lesions is a typical pathological feature of tuberculosis,and infection with Mycobacterium tuberculosis is the main cause.Although the mechanism underlying granuloma formation remains unclear,increasing evidence suggests that immune metabolism plays an important role.In this review,we summarized the latest advances in macrophage glycolytic reprogramming in tuberculosis granuloma formation to discover new methods for early diagnosis and provided new ideas for tuberculosis therapeutics based on the regulation of immune metabolism.

关 键 词：肉芽肿形成 结核肉芽肿 巨噬细胞 早期诊断 病理特征 结核分枝杆菌感染 结核病 药物治疗 

分 类 号：R52[医药卫生—内科学]