用于脂质体制备的微混合器的流动机理  

Flow mechanisms in micromixers for liposome production

作　　者：王康 刘心悦 胡国辉[1,2] WANG Kang;LIU Xinyue;HU Guohui(School of Mechanics and Engineering Science,Shanghai Institute of Applied Mathematics and Mechanics,Shanghai Key Laboratory of Mechanics in Energy Engineering,Shanghai Frontiers Science Center of Mechanoinformatics,Shanghai University,Shanghai 200072,China;Shanghai Institute of Aircraft Mechanics and Control,Shanghai 200092,China)

机构地区：[1]上海大学力学与工程科学学院,上海市应用数学和力学研究所,上海市力学在能源工程中的应用重点实验室,上海市力学信息学前沿科学研究基地,上海200072 [2]上海飞行器力学与控制研究院,上海200092

出　　处：《自然杂志》2023年第3期177-187,共11页Chinese Journal of Nature

基　　金：国家自然科学基金项目(12172209、11832017)。

摘　　要：脂质体的制备是当今纳米材料和生物医学工程研究的一个重要领域,尤其在制备粒度可控、尺寸均匀、组分可调的脂质体方面还面临着较大的挑战。微混合器作为微流控技术中的重要组成部分之一,它可以通过微米级通道控制流体的混合,从而实现高效、精准、可控的脂质体制备。文章概述了脂质体的制备方法及微流控技术的优势,并介绍了不同类型的微混合器在脂质体制备中的应用及优缺点,重点对微混合器的流动机理进行了综述,旨在为微混合器在脂质体制备中的应用研究提供一定的参考。The production of liposomes is an importantfield in the research of nanomaterials and biomedical engineering nowadays.Especially,the production of lipids with controllable particle size,uniform size and adjustable components still faces a significant challenge.Micromixers,as one of the important components of microfluidics,can control the mixing of fluids through micron-scale channels to achieve efficient,accurate and controllable liposome production.This review outlines the methods of liposome production and the advantages of microfluidics,and introduces the application,advantages and disadvantages of different types of micromixers in liposome production,focusing on the flow mechanisms of different types of micromixers,aiming to provide some reference for the study of the application of micromixers in liposome production.

关 键 词：脂质体 微混合器 流动机理 

分 类 号：TQ460.1[化学工程—制药化工]