基于数据挖掘探讨中医药治疗室性期前收缩的证候分布及用药特征  

Syndrome Distribution and Medication Characteristics of Traditional Chinese Medicine for Treatment of Ventricular Premature Beats Based on Literature Mining

作　　者：魏鹏路 尚菊菊[1] 刘红旭[1] 邢文龙[1] 贾文 武红莉[3] 谭玉培 龙德怀 李享[1] WEI Penglu;SHANG Juju;LIU Hongxu;XING Wenlong;JIA Wen;WU Hongli;TAN Yupei;LONG Dehuai;LI Xiang(Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China)

机构地区：[1]首都医科大学附属北京中医医院,北京100010 [2]武汉市中西医结合医院 [3]中国中医科学院中医临床基础医学研究所

出　　处：《中西医结合心脑血管病杂志》2023年第15期2705-2710,共6页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：国家自然科学基金青年科学基金项目(No.81704199);真实世界下活血化瘀类中成药对稳定性冠心病的多中心双向队列研究及循证团队建设(No.2019XZZX-XXG001);北京市医院管理局重点医学专业发展计划(No.ZYLX201817);北京市医管中心青苗人才项目(No.QML 20231003)。

摘　　要：目的:通过现代统计学方法探索中药治疗室性期前收缩的用药特点与组方规律。方法:检索中国知网(CNKI)、维普数据库(VIP)、万方数据库(WanFang Database)收录的2010年1月1日-2021年9月25日符合要求的文献,建立规范化数据库,进行证型分类统计,运用频数统计与关联规则(IBM SPSS Modeler 14.1 Premium软件,Apriori算法)分析主要证型用药特点与组方规律。结果:纳入方剂74首,涉及中药128味;涉及11个证型,以气阴两虚证、肝郁气滞证、气阴两虚夹瘀证、气血两虚证为主要证型,明确治疗主要证型处方的单味药用药频次,归纳常用药物组合;总结出4个主要证型的核心处方并进行比较,分析不同证型的用药与组方规律。气阴两虚证、气阴两虚夹瘀证、气血两虚证核心处方用药以补益药为主,包含益气、滋阴、补血,兼以清热、活血化瘀、安神;肝郁气滞证核心处方用药以平肝疏肝为主,兼理气。虚证或虚实夹杂证用药以麦冬、五味子、炙甘草、酸枣仁、当归等为主,实证以柴胡、生龙骨、生牡蛎、香附等为主,并根据病症变化及兼症,随证加减。结论:以频率统计与关联规则相结合方法挖掘治疗室性期前收缩的用药特点及核心处方,为室性期前收缩的治疗用药及新药研发提供了思路。Objective:To explore the characteristics of medication and prescription rules of traditional Chinese medicine in treating ventricular premature beats using modern statistical methods.Methods:The literature that met the requirements was retrieved from China National Knowledge Infrastructure(CNKI),VIP Database,and WanFang Database from January 1,2010,to September 25,2021,and a standardized database was established.IBM SPSS Modeler 14.1 Premium software,and Apriori algorithm were used to analyze the main syndrome type drug characteristics and prescription rules.Results:A total of 74 prescriptions and 128 traditional Chinese medicines were included,involving 11 syndrome types,and the main syndrome types were Qi and Yin Deficiency Syndrome,Liver Depression and Qi Stagnation Syndrome,Qi and Yin Deficiency and Stasis Syndrome,and Qi and Blood Deficiency Syndrome.The frequency of single drug in the prescriptions of the main syndrome types was summarized,and the popular combinations were summarized.The core prescriptions of the four main syndrome types were summarized and compared,and the rules of medication and prescriptions for different syndrome types were analyzed.Qi and Yin deficiency syndrome,Qi and Yin deficiency with blood stasis syndrome,and Qi and blood deficiency syndrome were mainly tonic drugs,including tonifying Qi,nourishing Yin,nourishing blood,combined with clearing away heat,promoting blood circulation and removing blood stasis,and calming the nerves.The core prescription drugs for stagnation syndrome were mainly to calm and soothe the liver and regulate Qi.For deficiency syndrome or mixed deficiency and excess syndrome,the main medicines were Maidong(ophiopogonis radix),Wuweizi(schisandrae chinensis fructus),Zhigancao(glycyrrhizae radix et rhizoma praeparata cum melle),Suanzaoren(ziziphispinosaesemen),Danggui(angelicae sinensis radix),while the empirical medicines were Chaihu(bupleuri radix),Shenglonggu(keel),Shengmuli(ostreae concha),Xiangfu(cyperi rhizoma),etc;medicines addition and subtraction were b

关 键 词：室性期前收缩 证型 临床研究 用药特征 数据挖掘 

分 类 号：R259[医药卫生—中西医结合]