儿童常见侵袭性肺部真菌病免疫机制和临床特点  

Clinical manifestations and immune mechanism of invasive pulmonary mycosis in children

作　　者：秦涛[1] 许红梅[1] QIN Tao;XU Hongmei(Children’s Hospital of Chongqing Medical University,National Clinical Research Center for Child Health and Disorders,Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing Key Laboratory of Child Infection and Immunity,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属儿童医院感染科、国家儿童健康与疾病临床医学研究中心、儿童发育疾病研究教育部重点实验室、儿童感染免疫重庆市重点实验室,重庆400014

出　　处：《临床儿科杂志》2023年第8期566-570,共5页Journal of Clinical Pediatrics

基　　金：重庆市首批公共卫生重点学科(专科)。

摘　　要：侵袭性肺部真菌病是由真菌引起的支气管肺部感染,出现气道黏膜炎症和肺部炎症肉芽肿,严重者可能导致坏死性肺炎,甚至血行播散到其他脏器。其发生发展取决于外界真菌致病因素和患者免疫功能的相互作用。儿童患有原发免疫功能缺陷、血液恶性肿瘤、接受造血干细胞移植或高强度免疫抑制剂应用,长期侵入性置管或者重症感染等情况均可能造成对真菌易感。文章对儿童侵袭性肺部真菌病的免疫学发病机制、临床表现特点要素进行探讨,希望能为疾病的早期发现提供理论依据。Invasive pulmonary mycosis is a fungal infection of the bronchi and lungs,causing inflammation of the airway mucosa and pulmonary inflammatory granulomas.In severe cases,necrotizing pneumonia may occur,and even hematogenous dissemination to other organs.Its occurrence and development depend on the interaction between external fungal pathogenic factors and the patient's immune function.Children with primary immune dysfunction,hematological malignancies,receiving hematopoietic stem cell transplantation or high-intensity immunosuppressive therapy,long-term invasive catheterization,or severe infections may be susceptible to fungi.This article discusses the immunological pathogenesis and clinical characteristics of invasive pulmonary mycosis in children,hoping to provide theoretical basis for the early detection of the disease.

关 键 词：侵袭性肺部真菌病 免疫学发病机制 临床表现 

分 类 号：R725.1[医药卫生—儿科]