心肌肌钙蛋白检测在儿科心脏受累相关疾病中的临床应用  

Clinical application of cardiac troponin determination in pediatric cardiac involvement related diseases

作　　者：杨琼 徐芬 蔺亚晖[1] YANG Qiong;XU Fen;LIN Yahui(Experimental Diagnostic Center,National Center for Cardiovascular Diseases,Fuwai Hospital of Chinese Academy of Medical Sciences,Beijing Key Laboratory of Molecular Diagnosis of Cardiovascular Diseases,Beijing 100037,China)

机构地区：[1]国家心血管病中心、中国医学科学院阜外医院实验诊断中心、心血管疾病分子诊断北京市重点实验室,北京100037

出　　处：《检验医学》2023年第6期510-517,共8页Laboratory Medicine

摘　　要：心肌肌钙蛋白(cTn)是心肌损伤敏感且特异的标志物。在成人中,cTn主要用于急性、慢性心肌损伤的诊断和危险分层。与成人不同,儿童患者心肌梗死和冠心病等心脏相关疾病的患病率较低,常见的心脏相关疾病为心肌炎、心包炎、先天性心脏病(CHD)等。同时,感染相关疾病、创伤、抗肿瘤药物等可累及心脏。cTn在儿童患者中具有一定的临床价值,但临床解读不尽相同。文章就cTn检测在儿科心脏受累相关疾病中的临床应用进行综述。Cardiac troponin(cTn)is a sensitive and specific marker of myocardial injury.In adults,cTn is widely used in the diagnosis of acute and chronic myocardial injury and risk stratification.Being different from adults,the prevalence of myocardial infarction and coronary heart diseases in children is low,and myocarditis,pericarditis and congenital heart disease(CHD)are common in children.Cardiac injury can occurred secondary to infection,trauma and cancer drug therapy in children.The indicator,cTn,is useful in all these clinical conditions with proper interpretations based on the pediatric patients.This review focuses on the clinical application of cTn determination in children.

关 键 词：心肌肌钙蛋白 儿童 心肌损伤 心血管疾病 非心血管疾病 

分 类 号：R446.1[医药卫生—诊断学]