TNF-α、IgM、IgG、补体C3与老年乙肝患者HBV-DNA水平的相关性及诊断肝纤维化的效能  

Correlations among of TNF-α,IgM,IgG,complement C3 and HBV-DNA level in elderly patients with hepatitis B and their efficacies in diagnosis of liver fibrosis

作　　者：黄晓辉 HUANG Xiaohui(Department of Clinical Laboratory of Xuchang Hospital,Xuchang 461000 Henan,China)

机构地区：[1]许昌医院检验科,河南许昌461000

出　　处：《中国民康医学》2023年第14期106-109,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨肿瘤坏死因子-α(TNF-α)、免疫球蛋白(Ig)M、IgG、补体C3水平与老年乙肝患者HBV-DNA水平的相关性及诊断肝纤维化的效能。方法:回顾性分析2017年9月至2020年5月该院收治的166例老年乙肝患者的临床资料,根据是否发生肝纤维化将其分为发生组52例和未发生组114例。比较两组HBV-DNA、TNF-α、IgM、IgG、C3水平,分析血清TNF-α、IgM、IgG、补体C3水平与HBV-DNA水平的相关性及四者在肝纤维化诊断中的效能。结果:发生组血清HBV-DNA、TNF-α、IgM、IgG水平均高于未发生组,补体C3水平低于未发生组,差异有统计学意义(P<0.05);Spearman相关性分析结果显示,血清TNF-α、IgM、IgG水平与HBV-DNA水平均呈正相关(r=0.832、0.558、0.721,P=0.000),补体C3水平与HBV-DNA水平呈负相关(r=-0.640,P=0.000);ROC曲线分析结果显示,血清TNF-α、IgM、IgG、补体C3水平单项及联合检测诊断肝纤维化的AUC依次为0.830、0.806、0.820、0.780、0.896,联合检测诊断效能最高。结论:血清TNF-α、IgM、IgG、补体C3水平与老年乙肝患者HBV-DNA水平存在相关性,且四者联合检测诊断肝纤维化的效能高于单项检测。Objective:To investigate correlations among tumor necrosis factor-α(TNF-α),immunoglobulin(Ig)M,IgG,complement C3 levels and HBV-DNA level in elderly patients with hepatitis B and their efficacies in diagnosis of liver fibrosis.Methods:The clinical data of 166 elderly patients with hepatitis B admitted to the hospital from September 2017 to May 2020 were retrospectively analyzed.According to whether liver fibrosis occurred,they were divided into occurrence group(52 cases)and non-occurrence group(114 cases).The levels of HBV-DNA,TNF-α,IgM,IgG and C3 were compared between the two groups.The correlations among the serum TNF-α,IgM,IgG,complement C3 levels and HBV-DNA level and their efficacies in the diagnosis of liver fibrosis were analyzed.Results:The levels of serum HBV-DNA,TNF-α,IgM and IgG in the occurrence group were higher than those in the non-occurrence group,the level of complement C3 was lower than that in the non-occurrence group,and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that serum TNF-α,IgM and IgG levels were positively correlated with HBV-DNA(r=0.832,0.558,0.721,P=0.000),and complement C3 level was negatively correlated with HBV-DNA(r=-0.640,P=0.000).ROC curve showed that the AUCs of single and combined detection of serum TNF-α,IgM,IgG and complement C3 levels in the diagnosis of liver fibrosis were 0.830,0.806,0.820,0.780 and 0.896,separately,and the diagnostic efficiency of combined detection was the highest.Conclusions:The serum TNF-α,IgM,IgG and complement C3 levels are correlated with HBV-DNA level in the elderly patients with hepatitis B,and the combined detection of the four is more effective in the diagnosis of liver fibrosis than single detection.

关 键 词：乙肝 老年 肿瘤坏死因子-α 免疫球蛋白 补体C3 肝纤维化 HBV-DNA 

分 类 号：R512.6[医药卫生—内科学] R575.2[医药卫生—临床医学]