红树林来源曲霉属和木霉属内生真菌次生代谢产物及活性研究进展  

Research progress on the secondary metabolites and activities of endophytic fungi of genus Aspergillus and Trichoderma from mangroves

作　　者：梁寒峭 陈文凤 范益铠 朱子冬 马国需[2] 陈德力[2,3] 田婧[1] LIANG Hanqiao;CHEN Wenfeng;FAN Yikai;ZHU Zidong;MA Guoxu;CHEN Deli;TIAN Jing(Department of Biomedicine,Beijing City University,Beijing 100083,China;Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100193,China;Hainan Branch Institute of Medicinal Plant Development(Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine),Chinese Academy of Medical Sciences&Peking Union Medical College,Haikou 570311,China)

机构地区：[1]北京城市学院生物医药学部,北京100083 [2]中国医学科学院北京协和医学院药用植物研究所,北京100193 [3]中国医学科学院北京协和医学院药用植物研究所海南分所海南省南药资源保护与开发重点实验室,海南海口570311

出　　处：《热带海洋学报》2023年第4期12-24,共13页Journal of Tropical Oceanography

基　　金：北京城市学院科研发展基金(KYF202003);北京城市学院2022年度研究生科研创新项目(Yjscx202243)。

摘　　要：红树林内生真菌因其高盐、高温、强光照、缺氧的生存环境而进化出独特的代谢途径,进而产生了一大批种类丰富、结构新颖、活性显著的次生代谢产物,使红树林来源的内生真菌次级代谢产物成为近年来的研究热点。在红树林内生真菌领域中,曲霉和木霉属真菌是研究较多的两个属。本文对2018年1月—2022年10月红树林来源曲霉属内生真菌和2015年1月—2022年10月红树林来源木霉属内生真菌新次级代谢产物的化学结构及其生物活性研究进行综述,按聚酮类、生物碱类、萜类、肽类与氨基酸类化合物等分别进行总结,并提出目前研究中存在的问题,为后续红树林内生真菌的研究提供借鉴和指导。Mangrove endophytic fungi has evolved a unique metabolic pathway due to its high salt,high temperature,strong light and anoxic living environment,and then produced a large number of secondary metabolites with rich species,novel structure and significant activity,making the secondary metabolites of mangrove endophytic fungi a research hotspot in recent years.In the field of mangrove endophytic fungi,Aspergillus and Trichoderma are two genera that have been studied frequently.This paper reviews the recent advance on the chemical structure and biological activity of new secondary metabolites of the endophytic fungi of genus Aspergillus from mangrove from January 2018 to October 2022 and the endophytic fungi of genus Trichoderma from mangrove from January 2015 to October 2022,summarizes them by polyketones,alkaloids,terpenoids and other compounds,and highlights the challenges in the current research.It can provide reference and guidance for the future study of mangrove endophytic fungi.

关 键 词：红树林 内生真菌 曲霉属 木霉属 代谢产物 生物活性 

分 类 号：P745.3[天文地球—海洋生物学]