Hippo信号通路在器官再生过程中的作用机制研究进展  

Research progress on the mechanism of Hippo signaling pathway in organ regeneration

作　　者：陈帅 李安鹏 李星星 赵庆杰 邹燕 CHEN Shuai;LI Anpeng;LI Xingxing;ZHAO Qingjie;ZOU Yan(School of Pharmacy,Naval Medical University,Shanghai 200433,China;92805 Military Hospital,Qingdao 266300,China)

机构地区：[1]海军军医大学药学系,上海200433 [2]92805部队医院,山东青岛266300

出　　处：《药学实践与服务》2023年第8期472-477,共6页Journal of Pharmaceutical Practice and Service

摘　　要：Hippo信号通路是多细胞动物体内调节细胞增殖和凋亡的主要信号通路之一,在组织稳态维持和器官生长调控中都发挥着非常重要的功能。大多数哺乳动物的再生潜力有限,近年来研究表明Hippo信号通路在多种组织器官的再生中至关重要。该综述主要介绍Hippo信号通路在器官再生中的作用以及相关靶点和抑制剂的研究进展,分析Hippo信号通路促进再生的机制,为器官再生相关疾病的治疗提供理论参考。Hippo signal pathway is one of the main signal pathways regulating cell proliferation and apoptosis in multicellular animals,which plays a vital role in the maintenance of tissue homeostasis and the regulation of organ growth.Most mammals have limited regenerative potential,and recent studies have shown that Hippo signal pathway is critical in the regeneration of various tissues and organs.The role of Hippo signaling pathway in organ regeneration and the research progress of related targets were introduced,the mechanism of Hippo signaling pathway promoting regeneration analyzes were aralyzed in this review,which provide theoretical reference for the treatment of diseases related to organ regeneration.

关 键 词：Hippo信号通路 器官再生 靶点 抑制剂 

分 类 号：R341[医药卫生—基础医学]