两种实验性疼痛的性别差异及其相关因素分析  

Gender differences of two experimental pain and analysis of relative factors

作　　者：宋兰娥 朱晓红 郝强[2] 李凯 SONG Lan-e;ZHU Xiaohong;HAO Qiang;LI Kai(Department of Anesthesiology,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China;Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;Department of Neurosurgery,Peking University International Hospital,Beijing 102206,China)

机构地区：[1]国家儿童医学中心首都医科大学附属北京儿童医院麻醉科,北京100045 [2]首都医科大学附属北京天坛医院神经外科,北京100070 [3]北京大学国际医院神经外科,北京102206

出　　处：《中国疼痛医学杂志》2023年第8期594-601,共8页Chinese Journal of Pain Medicine

基　　金：北京市自然科学基金(7204253)。

摘　　要：目的:调查女性对冷压痛是否存在与男性相同的行为二分法,根据此二分法检测袖带加压疼痛的性别差异,并分析心理因素与疼痛敏感度的相关性。方法:选择健康男性和女性各30例,根据冷压试验(cold-pressor test,CPT)的耐受时间(pain endurance time,PET)分为疼痛敏感组(pain-sensitive,PS)和疼痛耐受组(pain-tolerant,PT)。两组均进行袖带压力试验(cuff-pressure algometry test,CPA)。记录随时间变化的疼痛强度,并检测焦虑和恐惧水平。结果:女性在CPT中表现出与男性相同的行为二分法。但在CPA中女性PS组疼痛强度高于PT组,而两组男性无差异。女性PS组特质焦虑和恐惧高于PT组,两组男性无差异。CPA中女性PS组比男性PS组疼痛强度高,但女性PT组比男性PT组低。女性PS组特质焦虑高于男性PS组,而女性PT组低于男性PT组。女性CPT的PET与特质焦虑和恐惧水平均呈负相关,但男性却无相关性。结论:CPT中两性别均表现出行为二分法,但CPA中仅女性表现出行为二分法。疼痛的性别差异与心理因素有关,女性的疼痛敏感度与特质焦虑和恐惧的关系更为密切。Objective:To investigate whether women have the same behavioral dichotomy as men for cold pressor pain,and then detect gender differences in cuff-pressure pain according to this dichotomy,and analyze the correlation between psychological factors and pain sensitivity.Methods:Total of 30 healthy men and 30 healthy women were divided into pain-sensitive group(PS)and pain-tolerant group(PT)according to the pain endurance time(PET)of cold-pressor test(CPT).Cuff-pressure algometry test(CPA)was conducted for both groups.Pain intensity over time and the level of anxiety and fear were measured.Results:Women showed the same behavioral dichotomy as men in CPT.In CPA,the female PS group showed higher pain intensity than PT group,but there was no difference between the two groups of men.The level of trait anxiety and fear in female PS group was higher than that in PT group,but there was no difference between the two groups of men.In CPA,the pain intensity of female PS group was higher than that of male PS group,while that of female PT group was lower than that of male PT group.Female PS group showed higher trait anxiety than male PS group,while female PT group showed lower trait anxiety than male PT group.There was a negative correlation between PET of CPT and trait anxiety or fear level for female subjects,but no correlation was found for male subjects.Conclusion:Both sexes showed behavioral dichotomy in CPT,but only women showed this dichotomy in CPA.The gender difference in pain was affected by psychological factors.Women's pain sensitivity was more closely related to trait anxiety and fear levels.

关 键 词：疼痛的性别差异 冷压试验 袖带压力试验 状态-特质焦虑量表 恐惧量表 

分 类 号：R402[医药卫生—临床医学]