2020⁃2022年广西新型冠状病毒感染流行病学与病原学特征分析  

Analysis of Epidemiologic and Etiologic Characteristics of COVID⁃19 in the Guangxi,China from 2020 to 2022

作　　者：刘银品 蒋丽娜 曾竣[1,2] 居昱 莫建军[1,2] 李永红 董爱虎[1,2] 周树武 何为涛[1,2] 林玫 钟革[1,2] LIU Yinpin;JIANG Lina;ZENG Jun;JU Yu;MO Jianjun;LI Yonghong;DONG Aihu;ZHOU Shuwu;HE Weitao;LIN Mei;ZHONG Ge(Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response,Nanning 530028,China;Guangxi Center for Disease Control and Prevention,Nanning 530028,China)

机构地区：[1]广西重大传染病防控与生物安全应急响应重点实验室,南宁530028 [2]广西壮族自治区疾病预防控制中心,南宁530028

出　　处：《病毒学报》2023年第4期942-948,共7页Chinese Journal of Virology

基　　金：广西重点研发计划(项目号:桂科AB20149001),题目:新型冠状病毒肺炎流行规律与突发急性传染病综合监测信息系统建立。

摘　　要：分析2020⁃2022年期间广西新型冠状病毒感染(Coronavirus disease 2019,COVID⁃19)疾病的流行病学和病原学特征,为广西和其他地区COVID⁃19的疾病预防控制工作提供参考。搜集2020年1月1日⁃2022年12月7日期间广西报告的所有COVID⁃19病例信息和聚集性疫情资料,采用Excel 2010、SPSS20.0软件对数据进行分析和作图。2020⁃2022年期间广西累计报告COVID⁃19本地病例14119例,输入病例4455例,其中本地病例在所有县(市、区)均有报告,职业以家务及待业、农民为主;境外输入病例主要集中在边境的8个县(市、区),占94.84%,职业分布则以商业服务和工人为主;根据病例流行曲线及主要流行株可将广西这一时期COVID⁃19疫情分为3个阶段,第一阶段均由原始株导致;第二阶段以德尔塔株为主,占83.12%;第三阶段以奥密克戎株为主,占99.89%。对158起COVID⁃19聚集性疫情分析显示,引起内陆地区和边境地区聚集性疫情的变异株类型存在差异,且疫情来源不同,内陆地区的聚集性疫情79.70%因国内其他省份疫情波及导致,而边境地区68%因境外疫情输入,越南是广西边境地区境外输入性疫情的主要来源国。广西作为边境省份,境外输入导致的聚集性疫情与越南高度关联,且发生地区主要集中在8个边境县(市、区)的村屯;基因测序和流调结果提示广西边境地区聚集性疫情的变异株型别、好发场所均与内陆地区存在差异,因此制定两类地区的COVID⁃19防控措施上应有所不同。To analyze the epidemiological characteristics and etiology characteristics of COVID⁃19 cases in Guangxi,China during 2020⁃2022,and to provide scientific evidence for prevention and control of COVID⁃19,all the COVID⁃19 cases and clusters data reported in Guangxi,China from January 1,2020 to December 7,2022 were collected,and analyzed,mapped by Excel 2010,SPSS20.0.14,119 local cases and 4,455 imported cases were reported in Guangxi,China during 2020⁃2022.Local cases were distributed in all counties(cities and districts)in Guangxi,China,and the occupations were mainly housework,unemployed and farmers.The imported cases were mainly concentrated in 8 border areas,accounting for 94.84%,and the occupation distribution was mainly business service staff and workers.The COVID⁃19 epidemic in Guangxi,China during this period can be divided into three stages according to the epidemic curve of cases and the main epidemic strains.The first stage was caused by the original strain.The second stage was dominated by Delta variant,accounting for 83.12%.The third stage was dominated by Omicron strains,accounting for 99.89%.Analysis results of 158 reported clusters showed that there was a statistical difference in the type of variant causing clusters in inland and border areas,and the source of epidemic was different.79.70%of the clustered cases in inland areas were caused by the spread of the epidemic from other provinces of China,while 68%in border areas were caused by imported cases.Vietnam was the main source country of imported cases in Guangxi border areas,China.Guangxi,as a border province in China,the cluster events caused by imported cases was highly correlated with Vietnam,and the occurrence areas were mainly concentrated in the villages of 8 border areas.The results of gene sequencing and epidemiology survey suggested that the mutant strains and occurrence areas of clustered outbreaks in Guangxi border areas,China were different from those in inland areas.Therefore,the COVID⁃19 prevention and control measures

关 键 词：新型冠状病毒感染 变异株 流行特征 聚集性疫情 

分 类 号：R373.1[医药卫生—病原生物学]