蛋白质泛素化修饰对流感病毒增殖和致病性的影响  

Effects of Ubiquitination on Replication and Pathogenesis of Influenza Virus

作　　者：吴玉湖 胡欣妍 杨宣叶 王进千 高明阳 马忠仁[1,2] 周建华 WU Yuhu;HU Xinyan;YANG Xuanye;WANG Jinqian;GAO Mingyang;MA Zhongren;ZHOU Jianhua(Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission,Biomedical Research Center,Northwest Minzu University,Lanzhou 730030,China;Gansu Tech Innovation Center of Animal Cell,Biomedical Research Center,Northwest Minzu University,Lanzhou 730030,China;College of Life Science and Engineering,Northwest Minzu University,Lanzhou 730010,China)

机构地区：[1]西北民族大学,生物医学研究中心,生物工程与技术国家民委重点实验室,兰州730030 [2]西北民族大学,生物医学研究中心,甘肃省动物细胞技术创新中心,兰州730030 [3]西北民族大学,生命科学与工程学院,兰州730010

出　　处：《病毒学报》2023年第4期1152-1160,共9页Chinese Journal of Virology

基　　金：西北民族大学引进人才科研项目(项目号:Xb⁃muyjrc202225),题目:BVDV NS系列非结构蛋白与核糖体内部核糖体进入位点元件互作的结构功能域研究。

摘　　要：流感病毒是一种全球流行的呼吸道病原体,在其与宿主相互作用的过程中,病毒运用各种各样的方法逃避宿主抗病毒免疫系统的追击,而同时宿主也在不断武装自身免受病毒入侵,在这一系列过程中,泛素系统作为能够通过单个泛素或可逆性的泛素链与靶蛋白连接,进而使靶蛋白激活或失活的一种翻译后修饰机制。泛素化修饰在流感病毒复制过程中起到了至关重要的作用。因此,本篇综述结合近些年在此研究领域的研究成果,阐述了泛素化修饰参与病毒-宿主之间相互作用的机制,并为今后抗病毒药物的研发提供一个新的思路。Influenza virus is a globally prevalent human respiratory pathogen.During interaction between influenza virus and its susceptible hosts,the virus has evolved with various mechanisms for escaping host immune system;at the same time,host continues to arm itself with different antiviral immunity strategies in order to defense viral infection.Among these antiviral immunity strategies,the ubiquitin system is considered as one of important systems for antiviral activity.This system is a post-translational modification machinery for stimulation or deactivation of the target protein via reversible linkage of a single ubiquitin or ubiquitin chains.In addition,more and more evidences revealed that ubiquitination play an important role in replication of influenza virus.In this review,it is described that how the ubiquitination is involved in the life cycle of influenza virus in order to give new insights in developing new medicine pathways for influenza infection.

关 键 词：流感病毒 泛素系统 翻译后修饰 靶蛋白 病毒复制 

分 类 号：S852.65[农业科学—基础兽医学]