间充质干细胞治疗炎性关节炎的研究进展  

Progress in the treatment of inflammatory arthritis with mesenchymal stem cells

作　　者：冯星 靳洪涛[1] 马隽[2,4] 宋永周 刘爱京[1,4] Feng Xing;Jin Hongtao;Ma Jun;Song Yongzhou;Liu Aijing(Department of Rheumatology and Immunology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China;Department of Anatomy,Hebei Medical University,Shijiazhuang 050000,China;Department of Orthopedics,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China;Hebei Stem Cell Medical Transformation Engineering Research Center,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第二医院风湿免疫科,石家庄050000 [2]河北医科大学解剖教研室,石家庄050000 [3]河北医科大学第二医院骨科,石家庄050000 [4]河北省干细胞医学转化工程研究中心,石家庄050000

出　　处：《中华细胞与干细胞杂志（电子版）》2023年第2期87-92,共6页Chinese Journal of Cell and Stem Cell（Electronic Edition）

摘　　要：炎性关节炎(IA)是一组可累及多关节的慢性炎症性疾病,包括强直性脊柱炎、类风湿关节炎和银屑病关节炎等,早期诊断和治疗对患者预后尤为关键。目前临床主要治疗药物以非甾体类抗炎药、缓解病情抗风湿药以及靶向合成药物为主,但仍有部分患者存在疗效差、易复发和副作用大的问题。近年来,间充质干细胞(MSCs)因来源广泛、易获取、分化能力强、免疫调节及抗炎等优点被越来越多应用于IA的治疗。本文对MSCs治疗IA的作用机制、来源、剂量、给药方式和疗效等进行综述,旨在为IA的治疗提供新思路。Inflammatory arthritis(IA)is a group of chronic inflammatory diseases that influence multiple joints,including ankylosing spondylitis,rheumatoid arthritis,psoriatic arthritis,and so on.And early diagnosis and treatment are critical for the prognosis of patients.Currently,non-steroidal anti-inflammatory drugs,disease-modifying anti-rheumatic drugs,and biological agents are the main clinical drugs.However,some patients still suffer from poor efficacy,recurrence,and side effects.In recent years,mesenchymal stem cells(MSCs)have been increasingly applied in treating IA due to their advantages,such as various sources,easy access,strong differentiation potential,and immunomodulatory and anti-inflammatory abilities.This article reviewed the mechanisms,sources,dosages,administration methods,and efficacy of MSCs in treating IA,aiming to provide new ideas for the treatment of IA.

关 键 词：炎性关节炎 间充质干细胞 细胞治疗 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学] R68[医药卫生—基础医学]