骨形态发生蛋白在皮肤创面修复中的研究进展  

Development of bone morphogenetic protein in skin wound repair

作　　者：王湘 陈良熠 虞烽伟 王正熙 李秋彤 李玉红 Wang Xiang;Chen Liangyi;Yu Fengwei;Wang Zhengxi;Li Qiutong;Li Yuhong(Department of Cell Biology,Amy Medical University,Chongqing 400038,China;Department of Foreign Languages,Amy Medical University,Chongqing 400038,China)

机构地区：[1]陆军军医大学基础医学院细胞生物学教研室,重庆400038 [2]陆军军医大学基础医学院外语教研室,重庆400038

出　　处：《中华细胞与干细胞杂志（电子版）》2023年第2期101-107,共7页Chinese Journal of Cell and Stem Cell（Electronic Edition）

基　　金：国家自然科学基金(82173446)。

摘　　要：在创伤修复过程中,各类细胞因子与信号通路对于创伤修复的调控精密而复杂,长久以来一直是人们关注和探索的领域。其中转化生长因子-β(TGF-β),P38/MAPK,Wnt/β-catenin,PI3K/AKT等信号通路,在创伤修复中都有重要作用。TGF-β家族中的骨形态发生蛋白(BMP)是一组具有类似结构的高度保守的功能蛋白,既往研究发现其主要在诱导骨、软骨的形成和促进成骨细胞的生长等方面发挥作用。近年来,有研究发现,BMP可以通过信号通路促进或抑制另一种信号分子来调节各种皮肤相关细胞(如表皮干细胞、毛囊干细胞、成纤维细胞等)的活动,进而调节皮肤创伤修复过程。BMP作用于不同的细胞,对皮肤创伤修复的机制也不同。本文对BMP在创伤修复中的作用及最新研究进展予以综述。In trauma repair,regulating various cytokines and signaling pathways for trauma repair is sophisticated and complex,which has long been the field of attention and exploration.Among them,transforming growth factor-β(TGF-β),P38/MAPK,Wnt/β-catenin,PI3K/AKT and other signaling pathways play important roles in wound repair.Bone morphogenetic proteins(BMP)in the TGF-βfamily is a group of highly conserved functional proteins with similar structures.The previous research mainly focused on its function in inducing bone and cartilage formation and promoting osteoblast growth.However,recently ongoing studies have found BMP can promote or inhibit another signal molecule through the signaling pathways to regulate the activities of various skin-related cells,such as epidermal stem cells,hair follicle stem cells,fibroblasts,etc.,to regulate the process of skin wound repair.In this process,the mechanisms of BMP differ as it acts on different cells.This article reviews the role of BMP in wound repair and some latest findings.

关 键 词：骨形态发生蛋白 信号通路 皮肤创伤修复 

分 类 号：R64[医药卫生—外科学]