维生素C辅助奥曲肽治疗对急性胰腺炎患者肠黏膜屏障功能和外周血T淋巴细胞亚群的影响  

Effect of Vitamin C-assisted Octreotide Treatment on Intestinal Mucosal Barrier Function and Peripheral Blood T Lymphocyte Subsets in Patients with Acute Pancreatitis

作　　者：孙永刚 李海山[1] 徐礼友[1] 季流 王小银 郑婷婷 SUN Yong-gang;LI Hai-shan;XU Li-you;JI Liu;WANG Xiao-yin;ZHENG Ting-ting(Department of Emergency,The Second People's Hospital of Hefei,Hefei,Anhui,230000,China)

机构地区：[1]安徽省合肥市第二人民医院急诊科,安徽合肥230000

出　　处：《现代生物医学进展》2023年第13期2546-2549,共4页Progress in Modern Biomedicine

基　　金：安徽省医药卫生科技计划项目(C2021zyrc239)。

摘　　要：目的:探讨维生素C辅助奥曲肽治疗急性胰腺炎(AP)患者对肠黏膜屏障功能和外周血T淋巴细胞亚群的影响。方法:选取2020年1月~2022年1月安徽省合肥市第二人民医院收治的65例AP患者作为研究对象,使用信封法将其随机分为试验组(33例)和对照组(32例)。对照组予以奥曲肽^(+)常规治疗,试验组在对照组治疗基础上,另予维生素C治疗。比较两组患者治疗后胃肠功能恢复指标、治疗前后肠黏膜屏障功能和外周血T淋巴细胞亚群指标及不良反应。结果:治疗后,试验组患者腹痛消失时间、呕吐缓解时间、肠鸣音复常时间和肛门首次排气时间均明显少于对照组(P<0.05),且内毒素、二胺氧化酶(DAO)及D-乳酸水平均低于明显低于对照组(P<0.05);试验组CD8^(+)明显水平低于对照组(P<0.05),而CD4^(+)水平及CD4^(+)/CD8^(+)均显著高于对照组(P<0.05);试验组不良反应发生率(18.18%)与对照组(12.50%)无显著性差异(P>0.05)。结论:使用维生素C辅助奥曲肽治疗AP患者,可有效改善肠黏膜屏障功能和外周血T淋巴细胞亚群指标,安全性高。Objective:To explore the effect of vitamin C-assisted octreotide treatment on intestinal mucosal barrier function and peripheral blood T lymphocyte subsets in patients with acute pancreatitis(AP).Methods:A total of 65 patients with AP admitted to Hefei Second People's Hospital from January 2020 to January 2022 were randomly assigned to the experimental group(33 cases)and the control group(32 cases).The control group was given octreotide treatment and conventional treatment,while the experimental group was treated with vitamin C on this basis.Gastrointestinal function recovery indicators,intestinal mucosal barrier function,peripheral blood T lymphocyte subsets and adverse reactions were compared between groups.Results:After treatment,the disappearance time of abdominal pain,remission time of vomiting,recovery time of bowel sounds and first anal exhaust time in experimental group were significantly shorter than those in control group(P<0.05).The levels of endotoxin,diamine oxidase(DAO)and D-lactic acid were significantly lower than those in the control group(P<0.05).CD8^(+)in experimental group was significantly lower than that in control group(P<0.05),while CD4^(+)and CD4^(+)/CD8^(+)were significantly higher than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between experimental group and control group(18.18%vs.12.50%,P>0.05).Conclusion:Vitamin C-assisted octreotide treatment can effectively improve intestinal mucosal barrier function and peripheral blood T lymphocyte subsets in AP patients,with high safety.

关 键 词：维生素C 奥曲肽 急性胰腺炎 肠黏膜屏障功能 外周血T淋巴细胞亚群 

分 类 号：R657.5[医药卫生—外科学] R576[医药卫生—临床医学]