血清PA、CRP、PCT水平联合检测在老年细菌性肺炎患者诊断中的效果评价  

Effect Evaluation of Combined Detection of Serum PA,CRP and PCT Lev⁃els in the Diagnosis of Elderly Patients with Bacterial Pneumonia

作　　者：雷云静 赵东焕 师丽娟 LEI Yunjing;ZHAO Donghuan;SHI Lijuan(Department of Laboratory,Liaocheng Traditional Chinese Medicine Hospital,Liaocheng,Shandong Province,252000)

机构地区：[1]聊城市中医医院检验科,山东聊城252000

出　　处：《系统医学》2023年第9期13-17,共5页Systems Medicine

摘　　要：目的 以血清前白蛋白(prealbumin, PA)、C反应蛋白(C-reactive protein, CRP)、降钙素原(procalcitonin,PCT)水平检测数据进行老年细菌性肺炎的联合诊断工作,评价其具体效果。方法 随机选取2019年10月—2021年12月聊城市中医医院收治的老年肺炎患者100例为观察组,其中含有细菌感染者50例为细菌感染者组、非细菌感染者50例为非细菌感染组。再抽取同一时间段内于本院接受健康体检的人员100例为对照组。受试者均行以血清PA、CRP、PCT水平的单一、联合检测,根据检测结果开展各自组间的差异性比较。结果 与对照组相比,观察组的血清CRP、PCT水平更高,PA水平更低,差异有统计学意义(P<0.05)。与非细菌感染组相比,细菌感染者组的血清CRP、PCT水平更高,PA水平更低,差异有统计学意义(P<0.05)。100例老年肺炎患者经血清PA确诊为老年细菌性肺炎患者有40例(40.00%),经血清CRP确诊35例(35.00%),经血清PCT确诊45例(45.00%),经血清PA、CRP、PCT水平的联合检测确诊50例(50.00%)。和血清PA、CRP、PCT水平的单一检测结果相比,显示血清PA、CRP、PCT水平的联合检测结果的灵敏度更高,漏诊率更低,阴性预测值更高,差异有统计学意义(P<0.05)。结论 以血清PA、CRP、PCT水平检测数据进行老年细菌性肺炎的联合诊断工作,能够得到较高的灵敏度与阴性预测值,更低的误诊率、漏诊率,还能准确区分细菌性感染者、非细菌性感染者,应用价值极高。Objective To evaluate the specific effect of combined diagnosis of bacterial pneumonia in the elderly by detecting the levels of serum prealbumin(PA),C-reactive protein(CRP)and procalcitonin(PCT).Methods A total of 100 elderly patients with pneumonia admitted to Liaocheng Hospital of Traditional Chinese Medicine from October 2019 to December 2021 were randomly selected as the observation group,among which 50 cases of bacterial infection were in the bacterial infection group and 50 cases of non-bacterial infection were in the non-bacterial infection group.Then 100 healthy people who received physical examination in our hospital during the same period were selected as the control group.All subjects underwent single and combined detection of serum levels of PA,CRP and PCT,and the difference between each group was compared according to the detection results.Results Compared with the control group,the serum CRP and PCT levels in the observation group were higher and the PA levels were lower,and the dif‐ference was statistically significant(P<0.05).Compared with the non-bacterial infection group,the serum CRP and PCT levels in the bacteria-infected group were higher,and the levels of PA were lower,and the difference was statisti‐cally significant(P<0.05).Among the 100 patients with senile pneumonia,40(40.00%)were confirmed as senile bac‐terial pneumonia by serum PA,35(35.00%)by serum CRP,45(45.00%)by serum PCT,and 50(50.00%)by com‐bined detection of serum PA,CRP and PCT levels.Compared with the single detection results of serum PA,CRP and PCT levels,the combined detection results of serum PA,CRP and PCT levels showed higher sensitivity,lower missed diagnosis rate and higher negative predictive value,the difference was statistically significant(P<0.05).Conclusion The combined diagnosis of senile bacterial pneumonia with serum PA,CRP and PCT levels can obtain higher sensitiv‐ity and negative predictive value,lower misdiagnosis rate and missed diagnosis rate,and can accurately distinguish bacterial infection fro

关 键 词：血清PA CRP PCT 老年细菌性肺炎 灵敏度 误诊率 漏诊率 

分 类 号：R4[医药卫生—临床医学]