TIMP-2·IGFBP-7对成例肾病综合征急性肾损伤发生发展的预测价值  

Predictive Value of TIMP-2·IGFBP-7 in Occurrence and Development of Acute Kidney Injury in Adult Nephrotic Syndrome

作　　者：陈琦 丁秀和 李薇 李迎芝 CHEN Qi;DING Xiuhe;LI Wei;LI Yingzhi(Department of Renal Rheumatology and Immunology,Jinan Eighth People´s Hospital,Jinan,Shandong Province,)

机构地区：[1]济南市第八人民医院肾内风湿免疫科,山东济南271104

出　　处：《系统医学》2023年第9期21-24,共4页Systems Medicine

基　　金：济南市卫生健康委2021年科技计划项目(2021-2-61)。

摘　　要：目的 明确[TIMP-2]×[IGFBP-7]对成例肾病综合征急性肾损伤发生的预测价值。方法 选取2020年12月—2022年12月济南市第八人民医院收治的102例肾病综合征患者为研究对象,根据急性肾损伤(acute kidney injury, AKI)的发生情况分为AKI组(n=29)及非AKI组(n=73)。对比两组患者的TIMP-2、IGFBP-7、[TIMP-2]×[IGFBP-7]水平,并评估其预测价值。结果 AKI组入院时的TIMP-2、IGFBP-7、[TIMP-2]×[IGFBP-7]水平分别为(3.34±0.57)ng/mL、(159.48±28.95)ng/mL、(543.54±168.17)(ng/mL)2均高于非AKI组,差异有统计学意义(t=11.507、9.184、12.132,P<0.001)。[TIMP-2]×[IGFBP-7]预测AKI的AUC、95%CI、P值、约登指数、敏感度及阴性预测值均高于单一TIMP-2预测和IGFBP-7预测,差异有统计学意义(P<0.001)。结论 [TIMP-2]×[IGFBP-7]对肾病综合征发生AKI有早期预测价值,可为临床提供诊断依据,改善患者预后。Objective To determine the predictive value of[TIMP-2]×[IGFBP-7]for acute kidney injury in adult ne‐phrotic syndrome.Methods 102 patients with nephrotic syndrome admitted to the Eighth People´s Hospital of Jinan from December 2020 to December 2022 were selected as the research objects.According to the occurrence of Acute kidney injury(AKI),they were divided into AKI group(n=29)and non AKI group(n=73).Compared TIMP-2,IGFBP-7 and[TIMP-2]×[IGFBP-7]level between two groups of patients and evaluated its predictive value.Results The lev‐els of TIMP-2,IGFBP-7 and[TIMP-2]×[IGFBP-7]at admission of AKI group were(3.34±0.57)ng/mL,(159.48±28.95)ng/mL,and(543.54±168.17)(ng/mL)2,respectively,higher in the non AKI group,and the difference was statis‐tically significant(t=11.507,9.184,12.132,P<0.001).The AUC,95%CI,P value,Youden´s J statistic,sensitivity,and negative predictive value of AKI predicted by[TIMP-2]×[IGFBP-7]were higher than those predicted by single TIMP-2 and IGFBP-7,the difference was statistically significant(P<0.001).Conclusion[TIMP-2]×[IGFBP-7]has early predictive value for the occurrence of AKI in nephrotic syndrome,providing diagnostic basis for clinical practice and improving patient prognosis.

关 键 词：肾病综合征 急性肾损伤 TIMP-2 IGFBP-7 

分 类 号：R692[医药卫生—泌尿科学]