外周血T淋巴细胞亚群及免疫球蛋白检测在MPP患儿病情评估中的临床价值探究  

Clinical Value of Peripheral Blood T Lymphocyte Subsets and Immuno⁃globulin Detection in the Assessment of MPP Children

作　　者：王爱萍 WANG Aiping(Department of Laboratory,Zhaoyuan Branch of Shandong University Second Hospita,Zhaoyuan,Shandong Province,)

机构地区：[1]山东大学第二医院招远分院检验科,山东招远265400

出　　处：《系统医学》2023年第10期151-154,共4页Systems Medicine

摘　　要：目的 探究外周血T淋巴细胞亚群、免疫球蛋白检测在临床肺炎支原体肺炎(mycoplasma pneumoniae pneumonia, MPP)患儿病情评估中的价值。方法 选取2020年5月—2022年5月山东大学第二医院招远分院收治的MPP患儿104例作为研究对象,依据病情进展程度将其分为急性期组(54例)和恢复期组(50例),另选取同期在本院接受健康检查的正常儿童45例作为对照组,对比分析3组儿童T淋巴细胞亚群以及免疫球蛋白的差异。结果 与恢复期组和对照组相比,急性期组患儿的CD3+、CD4+、CD4+/CD8+下降显著,差异有统计学意义(P<0.05),NK细胞(22.55±5.66)%升高明显,差异有统计学意义(t=6.857、6.037,P<0.001),3组的CD8+和B细胞比较,差异无统计学意义(P>0.05)。急性期组的IgM水平(2.31±0.51)g/L明显高于恢复期组和对照组,差异有统计学意义(t=9.074、8.031,P<0.001);恢复期组的IgG水平(9.72±1.04)g/L显著高于急性期组和对照组,差异有统计学意义(t=4.652、3.502,P<0.001);对照组IgA水平(2.62±0.33)g/L高于急性期组和恢复期组,差异有统计学意义(t=10.564、10.519,P<0.001)。结论 临床上加强对MPP患儿外周血T淋巴细胞亚群、免疫球蛋白的检测,对于疾病的诊治具有重要参考价值。Objective To explore the value of T lymphocyte subsets and immunoglobulin detection in peripheral blood in the assessment of mycoplasma pneumoniae pneumonia(MPP).Methods A total of 104 children with MPP admitted to Zhaoyuan Branch of Shandong University Second Hospital from May 2020 to May 2022 were selected as the study subjects and divided into acute group(54 cases)and recovery group(50 cases)according to the degree of disease pro‐gression.Another 45 normal children who received health examination in our hospital during the same period were se‐lected as the control group.The differences of T lymphocyte subsets and immunoglobulin in 3 groups were compared and analyzed.Results Compared with convalescent group and control group,CD3+,CD4+and CD4+/CD8+in acute group were significantly decreased,the difference was statistically significant(P<0.05).NK cells(22.55±5.66)%in‐creased significantly,the difference was statistically significant(t=6.857,6.037,P<0.001).There were no statistically significant differences in CD8+and B cell results among the three groups(P>0.05).The IgM level in the acute stage group(2.31±0.51)g/L was significantly higher than that in the recovery stage group and the control group,the differ‐ence was statistically significant(t=9.074,8.031,P<0.001).The IgG level in convalescent group(9.72±1.04)g/L was significantly higher than that in acute group and control group,the difference was statistically significant(t=4.652,3.502,P<0.001).The IgA level in control group(2.62±0.33)g/L was higher than that in acute and convalescent groups,the difference was statistically significant(t=10.564,10.519,P<0.001).Conclusion Strengthening the detec‐tion of peripheral blood T lymphocyte subsets and immunoglobulin in children with MPP has important reference value for the diagnosis and treatment of the disease.

关 键 词：肺炎支原体肺炎 T淋巴细胞亚群 免疫球蛋白 

分 类 号：R446[医药卫生—诊断学]