GDF-15在心血管疾病中作用的研究进展  

Research progress on role of GDF-15 in cardiovascular diseases

作　　者：张秀华[1] 马丹[1] ZHANG Xiu-hua;MA Dan(Critical Care Unit,Department of Internal Medicine,First Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院内科危重症病房,黑龙江哈尔滨150001

出　　处：《心血管康复医学杂志》2023年第4期387-391,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：黑龙江省自然科学基金面上项目(H201446)。

摘　　要：目前对心血管疾病(CVD)的研究发现,在病理或应激条件下,心肌细胞中生长分化因子(GDF)-15的表达和分泌增加,对抑制心脏重构及心肌凋亡起有益作用,有望成为CVD的临床治疗新靶点。而且研究表明GDF-15可预测CVD的发生发展,可作为诊断CVD及评估预后的新型生物标志物。本文就GDF-15在CVD中的作用的研究进展作一综述。Current studies on cardiovascular diseases(CVD) have found that under pathological or stress conditions,expression and secretion of growth differentiation factor(GDF)-15 increases in cardiomyocytes,which plays a beneficial role in inhibiting cardiac remodeling and myocardial apoptosis,and is expected to become a new clinical treatment target for CVD.Moreover,researches indicated that GDF-15 can predict occurrence and development of CVD,and can be used as a novel biomarker to diagnose CVD and assess prognosis.The present article makes a review on research progress of role of GDF-15 in CVD.

关 键 词：心血管疾病 生长分化因子类 预测 

分 类 号：R54[医药卫生—心血管疾病]