Computational biology in topical bioactive peptide discovery for cosmeceutical application:a concise review  

作　　者：Xu-Hui Li Wen-Rou Su Fei-Fei Wang Ke Li Jing-Yong Zhu Si-Yu Zhu Si-Ning Kang Cong-Fen He Jun-Xiang Li Xiao Lin 

机构地区：[1]AGECODE R&D Center,Yangtze Delta Region Institute of Tsinghua University,Jiaxing 314000,China [2]Zhejiang Provincial Key Laboratory of Applied Enzymology,Yangtze Delta Region Institute of Tsinghua University,Jiaxing 314000,China [3]Yunnan Botanee Bio-technology Group Co.,Ltd.,Yunnan 650000,China [4]Yunnan Yunke Characteristic Plant Extraction Laboratory Co.,Ltd.,Yunnan 650000,China [5]Shenzhen Accompany Technology Co.,Ltd,Shenzhen 518000,China [6]College of Life Sciences and Medicine,Zhejiang Sci-tech University,Hangzhou 310018,China [7]Harvest Biotech(Zhejiang)Co.,Ltd.,Jiaxing 314000,China [8]School of Beijing Key Lab of Plant Resources Research and Development,Beijing Technology and Business University,Beijing 100048,China [9]School of Life Sciences,Northwestern Polytechnical University,Xi’an 710072,China

出　　处：《Biomedical Engineering Communications》2023年第3期7-15,共9页生物医学工程通讯

基　　金：supported by the Guangdong Basic and Applied Basic Research Foundation(No.2023A1515030047);Zhejiang Provincial Department of Agriculture and Rural Affairs(2022SNJF078).

摘　　要：Regenerative medicine and anti-aging research have made great strides at the molecular and cellular levels in dermatology and the medical aesthetic field,targeting potential treatments with skin therapeutic and intervention pathways,which make it possible to develop effective skin regeneration and repair ingredients.With the rapid development of computational biology,bioinformatics as well as artificial intelligence(A.I.),the development of new ingredients for regenerative medicine has been greatly accelerated,and the success rate has been improved.Some application cases have appeared in topical skin regeneration and repair scenarios.This review will briefly introduce the application of bioactive peptides in skin repair and anti-aging as emerging ingredients in cosmeceutics and emphasize how A.I.based computational biology technology may accelerate the development of innovative peptide molecules and ultimately translate them into potential skin regenerative and anti-aging scenarios.Typically,two research routines have been summarized and current limitations as well as directions were discussed for border applications in future research.

关 键 词：computational biology artificial intelligence COSMECEUTICAL bioactive peptide regenerative medicine 

分 类 号：O62[理学—有机化学]