新疆南部维吾尔族人群肾功能损伤现状及影响因素  

The status quo and influencing factors of renal impairment in the Uyghur population in southern Xinjiang

作　　者：郭小青 邵银宝 郭恒[1] 郭淑霞[1] 何佳[1] 李毓 马儒林[1] GUO Xiaoqing;SHAO Yinbao;GUO Heng;GUO Shuxia;HE Jia;LI Yu;MA Rulin(Department of Preventive Medicine,School of Medicine,Shihezi University,Shihezi 832000,China)

机构地区：[1]石河子大学医学院预防医学系,石河子832000

出　　处：《中华疾病控制杂志》2023年第7期800-806,共7页Chinese Journal of Disease Control & Prevention

基　　金：新疆生产建设兵团财政科技计划(2021AB030)。

摘　　要：目的了解新疆维吾尔自治区(新疆)南部维吾尔族人群肾功能损伤现状及其影响因素,为慢性肾脏病的早期发现和预防提供依据。方法选择2016年新疆生产建设兵团第三师51团≥18岁维吾尔族11782人作为调查对象,利用问卷调查、体格检查和实验室检测的数据,采用χ^(2)检验和非参数检验分析肾功能损伤程度差别;采用有序多分类logistic回归分析模型分析肾功能发生损伤程度的影响因素。结果在新疆南部维吾尔族人群中,发生肾功能损伤所占比例为20.7%,其中轻度肾功能损伤所占比例为19.5%,中重度肾功能损伤所占比例为1.1%,性别(χ^(2)=-14.871,P<0.001)、年龄(χ^(2)=884.842,P<0.001)、腰高比(χ^(2)=-12.088,P<0.001)、尿酸(uric acid,UA)(χ^(2)=-9.006,P<0.001)、FBG(χ^(2)=-7.156,P<0.001)、血脂异常(χ^(2)=-9.992,P<0.001)、高血压(χ^(2)=-13.706,P<0.001)、心血管疾病(cardiovascular disease,CVD)患病史(χ^(2)=-8.316,P<0.001)、CVD家族史(χ^(2)=-2.490,P=0.013)、嗜盐(χ^(2)=-2.373,P=0.018)组间差异均有统计学意义。女性(OR=2.373,95%CI:2.144~2.627,P<0.001)、高龄(OR=95.081,95%CI:63.375~142.651,P<0.001)、高尿酸血症(OR=2.277,95%CI:1.726~3.004,P<0.001)、血脂异常(OR=1.358,95%CI:1.222~1.508,P<0.001)、CVD家族史(OR=1.302,95%CI:1.072~1.580,P=0.008)均会加重肾功能损伤的程度。结论新疆南部维吾尔族人群中女性、高龄、高尿酸血症、血脂异常、CVD家族史是肾功能损伤的相关因素,同时上述因素均会加重肾功能损伤的程度。建议对重点人群进行健康教育和同伴教育,提升该人群对慢性肾病的知晓率、治疗率和控制率。Objective To analyze the current status of estimated renal impairment in the Uygur population in southern Xinjiang and explore its influencing factors,in order to provide evidence for the early detection and prevention of chronic kidney disease.Methods A total of 11782 Uyghurs over the age of 18 in the 51st Regiment of the Third Division of the Xinjiang Construction Corps in 2016 were selected as the survey subjects,and the data of a questionnaire survey,physical examination,and laboratory testing were used for analysis.The degree of renal injury distribution was described by theχ^(2) test and nonparametric test.The ordinal multi-class logistic regression model was used to explore the influencing factors of renal function injury.Results Among the Uyghur population in southern Xinjiang,20.7%had renal impairment,of which 19.5%had a mild renal impairment and 1.1%had moderate to severe renal impairment.There were significant differences in gender(χ^(2)=-14.871,P<0.001),age(χ^(2)=884.842,P<0.001),waist-to-height ratio(χ^(2)=-12.088,P<0.001),uric acid(UA)(χ^(2)=-9.006,P<0.001),fasting blood glucose(FBG)(χ^(2)=-7.156,P<0.001),dyslipidemia(χ^(2)=-9.992,P<0.001),hypertension(χ^(2)=-13.706,P<0.001),cardiovascular disease(CVD)history(χ^(2)=-8.316,P<0.001),CVD family history(χ^(2)=-2.490,P=0.013),and salt addiction(χ^(2)=-2.373,P=0.018).Being female(OR=2.373,95%CI:2.144-2.627,P<0.001),of advanced age(OR=95.081,95%CI:63.375-142.651,P<0.001),having hyperuricemia(OR=2.277,95%CI:1.726-3.004,P<0.001),dyslipidemia(OR=1.358,95%CI:1.222-1.508,P<0.001),and family history of CVD(OR=1.302,95%CI:1.072-1.580,P=0.008)were factors that aggravated the degree of renal damage.Conclusions In the Uyghur population in southern Xinjiang,being female,of advanced age,having hyperlipidemia,dyslipidemia,and a family history of CVD are influencing factors of renal impairment,which aggravated renal impairment.It is recommended to carry out health education and peer education for key groups to improve the awareness rate,treatment rate,and con

关 键 词：维吾尔族 估计肾小球滤过率 影响因素 

分 类 号：R195.1[医药卫生—卫生统计学] R692[医药卫生—卫生事业管理]