经导管主动脉瓣置换术在二叶式主动脉瓣狭窄中应用的研究进展  

Research progress of application of transcatheter aortic valve replacement in the bicuspid aortic valve stenosis

作　　者：李炜杰 罗建方 孙英皓 陈姣华 罗淞元[1] 李捷[1] LI Weijie;LUO Jianfang;SUN Yinghao;CHEN Jiaohua;LUO Songyuan;LI Jie(Department of Cardiology,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Southern Medical University,Guangzhou,510080,P.R.China;Department of Cardiology,The First People's Hospital of Foshan,Foshan,528000,Guangdong,P.R.China)

机构地区：[1]南方医科大学附属广东省人民医院,广东省医学科学院,广东省心血管病研究所心内科,广州510080 [2]佛山市第一人民医院心血管内科,广东佛山528000

出　　处：《中国胸心血管外科临床杂志》2023年第8期1199-1203,共5页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：广州市临床重大技术项目(2023FTJCZ0017);广东省冠心病防治重点实验室(Y0120220151)。

摘　　要：二叶式主动脉瓣(bicuspid aortic valve,BAV)的解剖结构不对称,钙化严重,常合并主动脉扩张。相比于三叶式主动脉瓣患者,BAV相关主动脉瓣狭窄(aortic valve stenosis,AS)患者在经导管主动脉瓣置换术(transcatheter aortic valve replacement,TAVR)治疗中,往往会面临更大的手术风险,包括瓣周漏、主动脉瓣环破裂、冠状动脉口堵塞、房室传导阻滞等。然而随着新一代人工瓣膜的出现以及手术策略的优化,目前多项研究均表明TAVR治疗BAV相关AS是安全有效的。本文将对TAVR在BAV相关AS患者中的应用进行综述。Patients with bicuspid aortic valve(BAV)are characterized by asymmetric anatomy,severe calcification and combined aortic dilatation.Compared with tricuspid aortic valve stenosis patients,patients with BAV stenosis confront with greater surgical risks in transcatheter aortic valve replacement(TAVR),including paravalvular leak,aortic valve rupture,coronary artery obstruction,atrioventricular block and so on.However,with the advent of new generation of prosthetic valves and optimization of surgical strategies,several studies have shown that TAVR is safe and effective in the treatment of BAV stenosis.Therefore,we aim to provide an overview of the use of TAVR in patients with BAV stenosis.

关 键 词：经导管主动脉瓣置换术 二叶式主动脉瓣 主动脉瓣狭窄 综述 

分 类 号：R654.2[医药卫生—外科学]