布鲁氏菌病传播危险因素的meta分析  

Meta-analysis of risk factors for brucellosis transmission

作　　者：陈奕瑾 石圆 于胜男 郑良 李秀君 CHEN Yijin;SHI Yuan;YU Shengnan;ZHENG Liang;LI Xiujun(Department of Biostatistics,School of Public Health,Shandong University,Jinan 250012,China)

机构地区：[1]山东大学公共卫生学院生物统计学系,山东济南250012

出　　处：《中国病原生物学杂志》2023年第8期892-898,共7页Journal of Pathogen Biology

摘　　要：目的通过Meta分析研究人类布鲁氏菌病传播的危险因素,如职业人群、环境条件等,为疫情预防和控制措施的制定提供参考。方法检索知网、万方、维普、PubMed、Embases数据库,收集国内外公开发表的关于人类布鲁氏菌病危险因素的研究文献,根据排除纳入标准对文献进行筛选,共纳入23篇文献。对纳入文献进行质量评分并提取数据资料,共纳入8个危险因素:不使用防护措施、饲养环境不定期消毒、买卖牲畜、接触流产物、知识掌握欠缺、吃生羊肉或病死肉、喝生羊奶、协助分娩。采用Stata16.0软件进行Meta分析,应用Meta分析的固定效应模型及随机效应模型综合定量评价布鲁氏菌病传播危险因素,并进行敏感性分析和发表偏倚检验。结果23篇纳入研究文献的Meta分析显示,不使用防护措施(OR=1.888,95%CI:0.801~2.976)、饲养环境不定期消毒(OR=2.387,95%CI:0.704~4.07)、买卖牲畜(OR=3.931,95%CI:1.024~6.839)、接触流产物(OR=1.719,95%CI:1.322~2.116)、知识掌握欠缺(OR=1.293,95%CI:0.073~1.513)、吃生羊肉或病死肉(OR=1.112,95%CI:0.548~1.677)、喝生羊奶(OR=1.282,95%CI:1.005~1.560)、协助分娩(OR=1.436,95%CI:0.867~2.005)均是人类布鲁氏菌病传播的危险因素。结论不使用防护措施、饲养环境不定期消毒、买卖牲畜、接触流产物、知识掌握欠缺、吃生羊肉或病死肉、喝生羊奶、协助分娩均是布鲁氏菌病传播主要危险因素,需要从传染源、传播途径、易感人群三个方面进行防控,相关部门应针对布鲁氏菌病制定有效的防控措施,如按时对工作环境进行消毒,加强对牲畜及其制品的检疫,加强对高危人群的健康教育,提倡群众养成良好的饮食习惯等,控制布鲁氏菌病的传播。Objective To study the risk factors of human brucellosis transmission through meta-analysis,such as occupational groups and environmental conditions,so as to provide countermeasures and suggestions for the prevention and control of brucellosis.Methods The published literatures on risk factors of human brucellosis were collected from CNKI,Wanfang,VIP,PubMed and Embases databases.A total of 23 literatures were included and screened by Inclusion and exclusion criteria.The quality scores of the literatures were scored and the data were extracted,including 8 risk factors:without protective measures,irregular disinfection of breeding environment,buying and selling livestock,contact with abortion products,lack of knowledge,eating raw mutton or sick and dead meat,drinking raw goat milk,assisted delivery.Stata16.0 software was used for meta-analysis.The fixed effects model and random effects model of meta-analysis were used to comprehensively and quantitatively evaluate the role of risk factors for brucellosis transmission,and sensitivity analysis and publication bias test were conducted.Results Meta-analysis of 23 articles showed that without protective measures OR=1.888(95%CI:0.801-2.976),irregular disinfection in breeding environment OR=2.387(95%CI:0.704-4.07),buying and selling livestock OR=3.931(95%CI:1.024-6.839),contact with abortion product OR=1.719(95%CI:1.322-2.116),lack of knowledge OR=1.293(95%CI:0.073-1.513),eating raw mutton or sick and dead meat OR=1.112(95%CI:0.548-1.677),drinking raw goat milk OR=1.282(95%CI:1.005-1.560)and assisted delivery OR=1.436(95%CI:0.867-2.005)were the main risk factors for the transmission of human brucellosis.Conclusion The main risk factors for brucellosis transmission include without protective measures,irregular disinfection of breeding environment,buying and selling livestock,contact with abortion products,lack of knowledge,eating raw mutton or sick and dead meat,drinking raw goat milk and assisted delivery.Prevention and control should be carried out from three aspects:sour

关 键 词：布鲁氏菌病 META分析 危险因素 

分 类 号：R516.7[医药卫生—内科学]