云南省北部地区6~12岁儿童棘球蚴病血清流行病学调查  

Serological survey on hydatid disease in children of 6-12 years in the northern region of Yunnan Province

作　　者：字金荣 杨亚明[1] 吴方伟[1] 严信留 彭佳[1] 蔡璇 王正青 李建雄[1] 徐倩 史帅 段承丽 李奔福[1] ZI Jinrong;YANG Yaming;WU Fangwei;YAN Xinliu;PENG Jia;CAI Xuan;WANG Zhengqing;LI Jianxiong;XU Qian;SHI Shuai;DUAN Chengli;LI Benfu(Yunnan Institute of Parasitic Diseases,Yunnan Provincial Collaborative Innovation Center for Public Health and Disease Prevention and Control(YPCICPHDPC),Dial University Institute of Pathogen and Vector Biology(Puer Divistion),Pu'er 665000,Yunnan,China;Diqing Prefecture Center for Disedse Control and Prevention;Nujiang Prefecture Center for Disedse Control and Prevention)

机构地区：[1]云南省寄生虫病防治所,云南省公共卫生与疾病控制协同创新中心,大理大学病原与媒介生物研究所(普洱分部),云南普洱665000 [2]迪庆州疾病预防控制中心 [3]怒江州疾病预防控制中心

出　　处：《中国病原生物学杂志》2023年第8期939-942,947,共5页Journal of Pathogen Biology

摘　　要：目的了解云南省北部地区6~12岁儿童棘球蚴病血清抗体水平。方法按照《全国包虫病流行病学调查方案》,于2013-2017年对迪庆、大理等9个州(市)的德钦、香格里拉、维西、洱源等28个县(市、区)采用分层抽样的方法抽取87所小学,对6~12岁儿童采集血样,采用ELISA法检测棘球蚴IgG抗体,组间血清抗体阳性率比较采用χ^(2)检验。结果共检测6~12岁儿童13913人,血清抗体阳性236人,阳性率为1.7%。9个州(市)中以迪庆州阳性率最高,为2.22%(92/4134);曲靖市阳性率最低,为0.64%(4/625)。28个县(市、区)中以剑川县阳性率最高,为3.18%(8/251);贡山县阳性率最低,为0.28%(1/349)。不同地州之间阳性率差异有统计学意义(χ^(2)=21.42,P<0.05)。男性儿童阳性率为2.01%(143/7109),女性儿童为1.37%(93/6804),差异有统计学意义(χ^(2)=8.54,P<0.01)。按年龄分组,以12岁组阳性率最高,为2.43%(85/3491);6岁组最低,为0.68%(3/436)。不同年龄组间阳性率差异无统计学意义(χ^(2)=11.91,P>0.05)。按调查地区生产方式分组,阳性率由高至低依次为:牧区2.41%(76/3149),半农半牧区1.93%(128/6629),农区0.77%(32/4135),差异有统计学意义(χ^(2)=33.11,P<0.01)。半农半牧区男女儿童阳性率分别为2.43%和1.42%,差异有统计学意义(χ^(2)=8.91,P<0.01)。藏族、白族、傈僳族、纳西族、彝族、汉族6个民族儿童占总调查儿童人数的96.56%(13435/13913),且主要聚集在滇西北地区,其中以牧区藏族儿童血清抗体阳性率较高,为2.6%(51/1960);其次为半农半牧区的白族儿童,为2.11%(58/2749),傈僳族1.82%(53/2879),纳西族1.68%(12/713),彝族1.46%(25/1708)。不同民族儿童阳性率差异有统计学意义(χ^(2)=22.87,P<0.01)。结论云南省北部地区儿童棘球蚴病血清抗体阳性率处于较低水平,但局部地区尚高,因此应进一步加强对当地儿童的健康教育并采取相应的防治措施,从而降低儿童感染包虫病的风险。Objective To understand the serum antibody levels of hydatid disease in children aged 6-12 years in the northern region of Yunnan Province.Methods Based on the national hydatid disease epidemiological investigation progarm,Children aged 6 to 12 years in 87 primary schools selected by stratified sampling were made in Deqin County,Shangri-La City,Weixi County,Eryuan County and other 28 counties(cities,districts)in Diqing regions,Dali regions and other 9 regions/cities)in northern Yunnan Province 2013 to 2017.The serum level of anti echinococcus IgG were determined by ELISA.Sero-positive rate of anti-echinococcosis antibody between groups were analyzed withχ^(2)test.Results A total of 13913 children were examined,and 236(1.7%)were positive for anti-echinococcus IgG.Among the regions of survey,the sero-positive rate was highest in Diqing regions(2.22%,92/4134),and lowest in Qujing City(0.64%,4/625).Among the counties of survey,the sero-positive rate was highest in Jian chuan County(3.18%,8/251),and lowest in Gong shan City(0.28%,1/349),Different sero-positive rates were observed in different regions/counties,which is statistically significant(χ^(2)=21.42,P<0.05).The sero-positive rate of male children was 2.01%(143/7109),and that of female children was 1.37%(93/6804),Different sero-positive rates were observed in different sex,which is statistically significant(χ^(2)=8.54,P<0.01).Among different age groups,the sero-positive rate was highest in the group of 12 years(2.43%,85/3491),and lowest in 6 year group(0.68%,3/436),Different sero-positive rates were observed in different age groups,which is no statistically significant(χ^(2)=11.91,P>0.05).Group groups by production mode in the survey area,The sero-positive rate was from high to low in order:2.41%(76/3149)in pastoral areas,1.93%(128/6629)in semi-agricultural and semi-pastoral areas,0.77%(32/4135)in agricultural areas,Different sero-positive rates were observed in different production modes,which is statistically significant(χ^(2)=33.11,P<0.01).The sero-positi

关 键 词：棘球蚴病 血清抗体 调查 儿童 云南省 

分 类 号：R532.32[医药卫生—内科学]