烯胺酮平台构建转化生物质产品Cyrene为增值化合物  

Engineering Biomass Feedstock Cyrene to Value-Added Compounds by Enaminone Platform Construction

作　　者：黄丽珠 刘云云 万结平 Huang Lizhu;Liu Yunyun;Wan Jieping(National Engineering Research Center for Carbohydrate Synthesis,College of Chemistry and Chemical Engineering,Jiangxi Normal University,Nanchang 330022;International Innovation Center for Forest Chemicals and Materials,Nanjing Forestry University,Nanjing 210037)

机构地区：[1]江西师范大学化学化工学院国家单糖化学合成工程技术研究中心,南昌330022 [2]南京林业大学林产化学与材料国际创新高地,南京210037

出　　处：《有机化学》2023年第6期2096-2103,共8页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(22161022)资助项目。

摘　　要：发展了在二氢左旋葡萄糖酮(Cyrene,昔兰尼)的酮α-位烯胺化构建烯胺昔兰尼(EC)的方法,有效地构建烯胺Cyrene作为平台合成子为将生物质产品Cyrene转化为增值化学品开辟了广阔的空间.在此研究中,实现了将烯胺昔兰尼向多种不同的手性有机衍生物,包括NH-/N,N-双取代结构的烯胺昔兰尼,氰基烯-和烯基磷修饰的昔兰尼,呋喃稠环结构的昔兰尼以及2,2-二氟二氢呋喃稠合的昔兰尼的转化.The enamination of Cyrene in the ketoneα-site leading to the enamino Cyrene(EC)has been developed.The practical preparation of EC as a platform synthon opens broad space of chemical transformation for Cyrene biomass feedstock in the synthesis of diverse value-added chemicals.In the present work,the transformation of the EC for the synthesis of many different chiral organic derivatives,including NH-/N,N-disubstituted ECs,the cyanoalkenyl-and vinyl phosphine oxide-elaborated Cyrene,Cyrene fused furan,and 2,2-difluorodihydrofuran fused Cyrene,has been realized.

关 键 词：昔兰尼 生物质产品 烯胺化 平台 增值 

分 类 号：TQ207[化学工程—有机化工] TK6[动力工程及工程热物理—生物能]