对烷氧基酚的合成及其去芳构化后的合成应用  

Synthesis of p-Alkoxy Phenol and Its Application after Dearomatization

作　　者：户晓兢 郭斐翔 朱润青 周柄棋 张涛 房立真[2] Hu Xiaojing;Guo Feixiang;Zhu Runqing;Zhou Bingqi;Zhang Tao;Fang Lizhen(The Third Affiliated Hospital of Xinxiang Medical University,Xinxiang,Henan 453003;School of Pharmacy,Xinxiang Medical University,Xinxiang,Henan 453003)

机构地区：[1]新乡医学院第三附属医院,河南新乡453003 [2]新乡医学院药学院,河南新乡453003

出　　处：《有机化学》2023年第6期2239-2244,共6页Chinese Journal of Organic Chemistry

基　　金：河南省科技厅高等学校学科创新引智基地(No.HNGD2021047);河南省教育厅高等学校重点科研(No.21A350008)资助项目。

摘　　要：以过渡金属钌(II)为催化剂,双三氟乙酰氧基碘苯(PIFA)为氧化剂,通过一步反应在烷氧基芳基醚对位选择性地实现羟基化,得到了对烷氧基苯酚(p-AOPs)类化合物.该类化合物去芳构化后,能方便地转化为醌单缩醛(QMAs),进一步与β-萘酚缩合可得到一些具有广泛应用前景的多环苯并呋喃化合物,为合成这类重要化合物提供了一种简洁可靠的途径.p-Alkoxy phenol(p-AOPs) compounds were obtained by one-step selective hydroxylation of alkoxyl-aryl ethers with the transition metal ruthenium(II) as catalyst and [bis(trifluoroacetoxy)iodo]benzene(PIFA) as oxidant.These p-AOPs could be easily converted to quinone monoacetals(QMAs) after dearomatization.Condensation of the QMAs with β-naphthols provided polycyclic benzofurans which have a wide application prospect.The protocol established in this paper offered a facile and reliable way for the synthesis of these important compounds.

关 键 词：过渡金属催化 区域选择性羟基化 C—H活化 对烷氧基苯酚 

分 类 号：O621.251[理学—有机化学]