肠道通透性与疾病关系的研究进展  

Research Progress in the Relationship Between Intestinal Permeability and Diseases

作　　者：林莹[1] 杨军红[1] LIN Ying;YANG Junhong(Nutritional Department,Tianjin Children's Hospital,Tianjin 300134,China)

机构地区：[1]天津市儿童医院营养科,天津300134

出　　处：《现代诊断与治疗》2023年第9期1305-1309,1422,共6页Modern Diagnosis and Treatment

摘　　要：肠道是吸收营养物质、抵御病原体及过敏原的重要结构。肠道通透性增加使肠道细胞屏障完整性丧失、中等大小的亲水分子在不借助载体系统的情况下顺浓度梯度非介导地透过肠道屏障,当肠道通透性增加时,病原体、过敏原等可经肠道进入体循环,损害靶器官。肠道疾病、自身免疫性疾病、肝脏疾病、代谢疾病、肾脏疾病等与肠道通透性增加有关,对肠道通透性进行评估并有效干预可能是延缓疾病发展的手段之一。The intestine is an important structure that absorbs nutrients and resists pathogens and allergens.The increase in intestinal permeability leads to the loss of intestinal cell barrier integrity,and medium-sized hydrophilic molecules can pass through the intestinal barrier non-mediatedlyalong the concentration gradient without the help of the carrier system.When the intestinal permeability increases,pathogensand allergens can enter the systemic circulation through the intestine and damage the target organs.Intestinal diseases,autoimmune diseases,liver diseases,metabolic diseases,andkidney diseases are associated with increased intestinal permeability.Assessment of intestinal permeability and effective intervention may be one the means to delay the development of the disease.

关 键 词：肠道通透性 紧密连接 肠道屏障 

分 类 号：R34[医药卫生—基础医学]