基于人工智能的肿瘤患者免疫相关不良反应管理软件的应用及效果评价  

Artificial intelligence-based software in the treatment and management of tumor patients with immune-related adverse reactions

作　　者：孙宝 罗芝英 傅媛媛[1,3] 张毕奎 刘文辉[1,2] SUN Bao;LUO Zhi-ying;FU Yuan-yuan;ZHANG Bi-kui;LIU Wen-hui(Department of Pharmacy,The Second Xiangya Hospital,Central South University,Changsha 410011;Institute of Clinical Pharmacy,Central South University,Changsha 410011;Liuyang Maternity and Infant Hosipital,Liuyang Hunan 410399)

机构地区：[1]中南大学湘雅二医院药学部,长沙410011 [2]中南大学临床药学研究所,长沙410011 [3]浏阳市妇幼保健院,湖南浏阳410399

出　　处：《中南药学》2023年第8期2228-2231,共4页Central South Pharmacy

基　　金：国家自然科学基金项目(No.82104307);湖南省自然科学基金项目(No.2021JJ40865,No.2021JJ40486)。

摘　　要：目的探索基于人工智能的肿瘤患者免疫相关不良反应管理软件的应用及效果评价。方法通过采集接受免疫检查点抑制剂肿瘤患者住院、门诊及居家的全病程信息数据,构建医学相关知识库,对患者数据进行智能提取和分析后推荐管理方案,最后以患者免疫相关不良反应发生率作为评价指标进行效果评价。结果通过对肿瘤患者信息以及相关指南、文献、药品说明书等信息的抽提和融合,构建了智能医学知识库。随后,智能医学知识库可以在不同场景下给肿瘤患者推荐个体化治疗和管理方案。患者免疫相关不良反应发生率由38.5%降至31.2%。结论基于人工智能的肿瘤患者免疫相关不良反应管理对降低临床患者不良反应有较大帮助,可以提升并优化肿瘤患者治疗和自我管理的质量。Objective To evaluate the effect of artificial intelligence on immune-related adverse reaction management in tumor patients.Methods Through collecting data of inpatients,outpatients and home disease course information of cancer patients received immune checkpoint inhibitors,the medical knowledge related data base was established.Data of patient was analyzed before recommending the management plan.Finally,the incidence of immune-related adverse reactions was used as an index to evaluate the effect.Results Through summarizing tumor patient information,related guidelines,literatures,drug instructions and other information,the intelligent medical knowledge base was constructed,which could recommend individualized treatment options for cancer patients in different scenarios.The incidence of immune-related adverse reactions decreased from 38.5%to 31.2%.Conclusion The management of immune-related adverse reactions in tumor patients based on artificial intelligence helps reduce adverse reactions in clinical practice,and optimize the quality of treatment and self-management of tumor patients.

关 键 词：人工智能 肿瘤患者 免疫相关不良反应 智能医学知识库 治疗和管理 

分 类 号：R95[医药卫生—药学]