大肠息肉证候与用药规律的文献研究  

TCM Syndromes and Medication Rules of Colorectal Polyps

作　　者：黄远程 黄超原 沈丹婷 田燕华 邹雨杉 文艺[3] 李培武[3] 刘凤斌[3,4] HUANG Yuancheng;HUANG Chaoyuan;SHEN Danting;TIAN Yanhua;ZOU Yushan;WEN Yi;LI Peiwu;LIU Fengbin(Cancer Center,the Tenth Affiliated Hospital of Southern Medical University,Dongguan People′s Hospital,Dongguan 523018,China;First Clinical Medical College,Guangzhou University of Chinese Medicine,Guangzhou 510006,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Baiyun Hospital of the First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510470,China)

机构地区：[1]南方医科大学第十附属医院广东省东莞市人民医院肿瘤中心,东莞523018 [2]广州中医药大学第一临床医学院,广州510006 [3]广州中医药大学第一附属医院,广州510405 [4]广州中医药大学第一附属医院白云医院,广州510470

出　　处：《世界中医药》2023年第15期2209-2214,共6页World Chinese Medicine

基　　金：国家中医药管理局区域中医(专科)诊疗中心建设与培育项目(国中医药医政函〔2018〕205号);刘凤斌广东省名中医传承工作室(粤中医办函〔2020〕1号)。

摘　　要：目的:探讨结直肠息肉(CRP)的证候证素分布规律及用药规律。方法:检索各大中文数据库,依据纳入和排除标准,纳入有关CRP的中医临床研究。收集文献的病例辨证分型、处方用药,以Microsoft EXCEL 2016建立数据库,应用SPSS 22.0分析CRP证候证素分布规律,应用中医传承辅助平台(V2.5)对CRP的组方规律进行描述性统计、关联规则分析。结果:共纳入文献112篇,其中证候类研究42篇,用药类研究70篇。大肠湿热证、脾虚湿蕴证、湿阻肠道证、脾肾阳虚证、脾胃气虚证为CRP主要证候类型。CRP病位在脾、大肠、肾、肝、胃,常见病性类证素依次为湿、气虚、热、气滞、瘀血、阳虚。CRP所涉及的94首中药处方经规范后共包含中药156味,基于支持度为10%、15%、20%和置信度为60%的筛选标准下进行关联规则分析,分别得到药物间关联规则450、63、27条,主要用药组合21、9、6个。结论:CRP为本虚标实、虚实夹杂之证,本虚主要是脾气(阳)虚、肾阳虚,标实主要是大肠湿热、血瘀,病位在脾胃与大肠,与肾、肝密切相关,湿、气虚、热、气滞、瘀血、阳虚是其关键病理因素,以健脾渗湿为基本大法,以参苓白术散加减为基础方,辅以温补、清热、理气、活血等法。Objective:To reveal the distribution features of traditional Chinese medicine(TCM)syndromes and syndrome elements and the medication rules of colorectal polyps(CRP).Methods:The clinical studies about the TCM treatment of CRP were retrieved from major Chinese academic journal databases and screened based on inclusion and exclusion criteria.The syndromes and TCM prescriptions were extracted from the included articles and used to establish a library in Microsoft EXCEL 2016.SPSS 22.0 was used to analyze the distribution rules of TCM syndromes and syndrome elements,and the Traditional Chinese Medicine Inheritance Support System(V2.5)to conduct descriptive statistics and association rule mining.Results:A total of 112 articles(42 articles about TCM syndromes and 70 about medications)were included in this study.The common syndromes of CRP were heat and dampness of large intestine,spleen deficiency and dampness stagnation,dampness obstructing intestine,yang deficiency of spleen and kidney,and qi deficiency of spleen and stomach.The major locations of CRP were spleen,large intestine,kidney,liver,and stomach.The frequent syndrome elements of CRP were dampness,qi deficiency,heat,qi stagnation,blood stasis,and yang deficiency.The 94 prescriptions for treating CRP contained 156 herbs.The association rules were mined under the conditions of support being 10%,15%,and 20%and the confidence being 60%,which yielded 21,9,and 6 core drug combinations and 450,63,and 27 association rules,respectively.Conclusion:CRP is caused by internal deficiency and external excess,with the combination of deficiency and excess.The internal deficiency mainly involves qi(yang)deficiency of the spleen and yang deficiency of the kidney.The external excess is reflected in heat and dampness of large intestine and blood stasis.The disease mainly attacks the spleen and large intestine and is closely related to the kidney and liver.The primary syndrome elements were dampness,qi deficiency,heat,qi stagnation,blood stasis,and yang deficiency.The treatment of CR

关 键 词：结直肠息肉 文献研究 数据挖掘 中医传承辅助平台(V2.5) 证候 证素 用药规律 

分 类 号：R284[医药卫生—中药学] R273[医药卫生—中医学]