NLR与Framingham心血管疾病风险等级的相关性及对高危心血管疾病的预测价值  

Correlation of NLR with Framingham cardiovascular disease risk rating and its predictive value for high-risk cardiovascular disease

作　　者：李萌 LI Meng(Department of Cardiology,Zaozhuang Municipal Hospital,Zaozhuang 277000,China)

机构地区：[1]枣庄市立医院心内科,277000

出　　处：《中国实用医药》2023年第15期44-47,共4页China Practical Medicine

摘　　要：目的利用Framingham模型对高危心血管疾病患者中性粒细胞与淋巴细胞比值(NLR的高低变化与心血管疾病风险等级的相关性以及其对于高危心血管疾病的预测价值进行评价。方法选择80例原发性高血压患者作为观察组,选取同时间内非高血压人群90例作为对照组。再根据Framingham心血管疾病风险等级评分结果将观察组患者分为低危组(53例)以及高危组(27例)。比较三组患者的临床基本信息及白细胞分类,分析Framingham心血管疾病风险等级与NLR的相关性。结果三组患者的性别、吸烟占比、低密度脂蛋白胆固醇(LDL-C)、丙氨酸氨基转移酶(ALT)、甘油三酯(TG)、空腹血糖(FBG)、肌酐(Cr)比较,差异无统计学意义(P>0.05);三组患者的年龄、体质量指数(BMI)、收缩压、舒张压、糖尿病占比、服用β-受体阻滞剂占比、服用钙离子拮抗剂占比、服用利尿药占比、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、左心室射血分数(LVEF)比较,差异具有统计学意义(P<0.05)。低危组的年龄、收缩压、舒张压、糖尿病占比、服用β-受体阻滞剂占比、服用钙离子拮抗剂占比、服用利尿药占比、TC均高于对照组,HDL-C、LVEF均低于对照组,差异具有统计学意义(P<0.05);高危组的年龄、BMI、收缩压、舒张压、糖尿病占比、服用β-受体阻滞剂占比、服用钙离子拮抗剂占比、服用利尿药占比、TC均高于对照组,HDL-C、LVEF均低于对照组,差异具有统计学意义(P<0.05);高危组的年龄、BMI、收缩压、TC均高于低危组,LVEF低于低危组,差异具有统计学意义(P<0.05)。对照组患者的白细胞计数、单核细胞比例、NLR分别为(8.04±1.02)×10^(9)/L、(4.55±2.27)%、(2.18±0.47),低危组分别为(9.92±1.07)×10^(9)/L、(6.96±2.99)%、(2.77±0.57),高危组分别为(11.74±2.17)×10^(9)/L、(8.62±3.95)%、(3.51±0.44)。三组患者的白细胞计数、单核细胞比例、NLR比较,差异具有统�Objective To investigate the correlation of neutrophil to lymphocyte ratio(NLR)with Framingham cardiovascular disease risk rating and its predictive value for high-risk cardiovascular disease.Methods 80 patients with essential hypertension were selected as the observation group,and 90 patients without hypertension during the same time were selected as the control group.According to the results of Framingham cardiovascular disease risk rating,the observation group was divided into low-risk group(53 cases)and high-risk group(27 cases).The clinical basic information and leukocyte classification of the three groups were compared,and the correlation between Framingham cardiovascular disease risk rating and NLR was analyzed.Results There was no statistically significant difference in gender,smoking proportion,low density lipoprotein cholesterol(LDL-C),alanine aminotransferase(ALT),triglyceride(TG),fasting blood glucose(FBG)and creatinine(Cr)among three groups(P>0.05).The age,body mass index(BMI),systolic blood pressure,diastolic blood pressure,proportion of diabetes mellitus,proportion of oralβ-blockers,proportion of calcium antagonists,proportion of oral diuretics,total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),and left ventricular ejection fraction(LVEF)of the three groups were compared,and the differences were statistically significant(P<0.05).Age,systolic blood pressure,diastolic blood pressure,proportion of diabetes mellitus,proportion of oralβ-blockers,proportion of oral calcium antagonists,proportion of oral diuretics and TC in low-risk group were higher than those in control group;HDL-C and LVEF in low-risk group were lower than those in control group;the differences were statistically significant(P<0.05).Age,BMI,systolic blood pressure,diastolic blood pressure,proportion of diabetes mellitus,proportion of oralβ-blockers,proportion of oral calcium antagonists,proportion of oral diuretics and TC in high-risk group were higher than those in control group;HDL-C and LVEF in low-risk group were

关 键 词：中性粒细胞与淋巴细胞比值 Framingham心血管疾病风险等级 高危心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]