慢性阻塞性肺疾病患者住院期间发生肺栓塞的危险因素分析  

Risk factors of pulmonary embolism in patients with chronic obstructive pulmonary disease during hospitalization

作　　者：刘艳洁 余瑞雪 王莉 陈晓勇[1] 丁玉英[2] Liu Yanjie;Yu Ruixue;Wang Li;Chen Xiaoyong;Ding Yuying(Department of General Medicine,Bozhou People's Hospital,Bozhou 236800,Anhui,China;Department of Vascular Surgery,Bozhou People's Hospital,Bozhou 236800,Anhui,China)

机构地区：[1]亳州市人民医院全科医学科,安徽亳州236800 [2]亳州市人民医院血管外科,安徽亳州236800

出　　处：《血管与腔内血管外科杂志》2023年第7期881-884,共4页Journal of Vascular and Endovascular Surgery

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)患者住院期间发生肺栓塞的危险因素。方法收集2020年1月至2022年12月于亳州市人民医院住院接受治疗的126例COPD患者的临床资料,按照住院期间是否发生肺栓塞将其分为肺栓塞组(n=19)和对照组(n=107)。收集所有患者入院时的一般资料,分析COPD患者住院期间发生肺栓塞的影响因素,比较两组患者机械通气、低分子肝素、糖皮质激素以及阿司匹林使用情况。结果肺栓塞组患者的年龄、体重指数、肺部感染率均高于对照组患者,差异均有统计学意义(P﹤0.05)。多因素分析结果显示,年龄≥65岁、体重指数﹥28 kg/m^(2)以及肺部感染均是COPD患者住院期间发生肺栓塞的独立危险因素(P﹤0.05)。肺栓塞组患者机械通气、低分子肝素、糖皮质激素、阿司匹林使用率均高于对照组患者,但差异均无统计学意义(P﹥0.05)。结论年龄≥65岁、体重指数﹥28 kg/m^(2)以及肺部感染均是COPD患者住院期间发生肺栓塞的独立危险因素,临床实践中可以根据患者的具体情况进一步作出初步的判断。Objective To analyze the risk factors of pulmonary embolism in patients with chronic obstructive pulmonary disease(COPD)during hospitalization.Method The clinical data of 126 COPD patients hospitalized in the Bozhou People's Hospital from January 2020 to December 2021 were collected.All patients were divided into the pulmonary embolism group(n=19)and the control group(n=107)according to presence of pulmonary embolism during hospitalization.Baseline data of all patients at admission were collected to analyze the influencing factors of pulmonary embolism in COPD patients during hospitalization,and the mechanical ventilation,low molecular weight heparin,glucocorticoid and aspirin were compared between the two groups.Result The average age,body mass index and the rate of pulmonary infection in the pulmonary embolism group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).Multivariate analysis showed that the age≥65 years old,body mass index>28 kg/m^(2) and pulmonary infection were independent risk factors for pulmonary embolism in COPD patients during hospitalization(P<0.05).The rate of mechanical ventilation,low molecular weight heparin,glucocorticoid and aspirin in pulmonary embolism group were higher than that in control group,but there were no statistical significances(P>0.05).Conclusion Age≥65 years old,body mass index>28 kg/m^(2) and pulmonary infection are independent risk factors for pulmonary embolism in COPD patients during hospitalization.Clinicians make preliminary judgment based on conditions of patients.

关 键 词：慢性阻塞性肺疾病 肺栓塞 危险因素 

分 类 号：R543[医药卫生—心血管疾病]