Using Network Pharmacology to Explore the Mechanism of Capsicum in Treating Type 2 Diabetes Mellitus  

作　　者：Yunfeng BAI Yuxin HANG Ning XU Jinglin LIU Liang XU 

机构地区：[1]College of Chemistry and Materials Science,Inner Mongolia Minzu University/Key Laboratory of Natural Product Chemistry and Functional Molecular Synthesis of Inner Mongolia Autonomous Region,Tongliao 028000,China

出　　处：《Medicinal Plant》2023年第4期27-30,45,共5页药用植物：英文版

基　　金：Supported by National Natural Science Foundation of China(81560702);Inner Mongolia Natural Science Foundation(2022LHMS08021).

摘　　要：[Objectives] The paper was to explore the mechanism of capsicum ( Capsicum annuum L.) in treating type 2 diabetes mellitus (T2DM) and search for new targets. [Methods] The active ingredients of capsicum were queried from TCMSP database to obtain the corresponding target proteins. The related targets of T2DM were screened from GeneCards database, and the target intersection of active ingredients of capsicum and diabetes mellitus was obtained via Venny software. The protein-protein interaction (PPI) network of the compounds was constructed using STRING database, and the GO bio-function and KEGG pathway enrichment were further analyzed using Metascape database. [Results] Through TCMSP database query and conditional screening, 14 candidate active molecules, 93 potential targets and 225 related pathways were obtained. [Conclusions] The results of GO and KEGG enrichment analysis show that the main active ingredients of capsicum play a role in the treatment of T2DM by regulating cancer pathways, chemical carcinogenesis—receptor activation, proteoglycans in cancer, and prostate cancer pathways, which will provide an important theoretical basis for subsequent research.

关 键 词：Network pharmacology CAPSICUM Type 2 diabetes mellitus Mechanism of action 

分 类 号：R285[医药卫生—中药学]