小儿病毒性脑炎继发癫痫患儿脑电图特点、临床特征及危险因素研究  

Study of electroencephalogram characteristics,clinical characteristics and risk factors in children with epilepsy secondary to viral encephalitis

作　　者：丁博 雷智贤 朱乃云 DING Bo;LEI Zhi-xian;ZHU Nai-yun(Department of Child Neurology,Hainan Women and Children's Medical Center,Haikou 570206,Hainan,China;Department of Child Critical Medicine,Hainan Women and Children's Medical Center,Haikou 570206,Hainan,China)

机构地区：[1]海南省妇女儿童医学中心儿童神经内科,海南海口570206 [2]海南省妇女儿童医学中心儿童重症医学科,海南海口570206

出　　处：《川北医学院学报》2023年第8期1030-1032,1057,共4页Journal of North Sichuan Medical College

基　　金：海南省自然科学基金面上项目(819MS129)。

摘　　要：目的:分析小儿病毒性脑炎(VE)继发癫痫(EP)患儿脑电图(EEG)特点、临床特征及危险因素。方法:选取90例VE患儿作为研究对象,根据是否继发EP将患儿分为EP组(n=21)和非EP组(n=69),分析两组EEG特点、临床特征,采用Logistic回归分析影响VE继发EP的危险因素。结果:EP组患儿EEG异常情况高于非EP组(P<0.05)。EP组患儿家族EP史、呕吐、昏迷、颅脑MRI有责任病灶比例均高于非EP组(P<0.05)。Logistic回归分析,EEG重度异常、昏迷和颅脑MRI有责任病灶均为影响VE患儿继发EP的独立危险因素(OR=10.125、10.444、8.953,P<0.05)。结论:VE继发EP患儿EEG重度异常比例较高,且EEG重度异常、昏迷和颅脑MRI有责任病灶均为继发EP的危险因素。Objective:To analyze electroencephalogram(EEG)characteristics,clinical characteristics and risk factors in children with epilepsy(EP)secondary to viral encephalitis(VE).Methods:90 children with VE were selected as the research subjects.According to presence or absence of secondary EP,they were divided into EP group(n=21)and non-EP group(n=69).EEG characteristics and clinical characteristics in both groups were analyzed.The risk factors of secondary EP in VE were analyzed by Logistic regression analysis.Results:The proportion of abnormal EEG in EP group was higher than that in non-EP group(P<0.05),and proportions of cases with family EP history,vomiting,coma and responsible lesions in brain MRI were higher than those in non-EP group(P<0.05).Logistic regression analysis showed that severe EEG abnormality,coma and responsible lesions in brain MRI were independent risk factors of secondary EP in VE children(OR=10.125,10.444,8.953,P<0.05).Conclusion:The proportion of severe EEG abnormality is high in children with EP secondary to VE.Severe EEG abnormality,coma and responsible lesions in brain MRI are risk factors of secondary EP.

关 键 词：病毒性脑炎 继发癫痫 脑电图 临床特征 危险因素 

分 类 号：R725.1[医药卫生—儿科]