血清PLGF、IGF-1及sFLT-1水平对子痫前期孕妇妊娠结局的预测价值  

Predictive value of serum PLGF,IGF-1,and sFLT-1 levels on pregnancy outcomes in preeclampsia pregnant women

作　　者：赵晓爽 胡玉博[1] 朱林凤 ZHAO Xiao-shuang;HU Yu-bo;ZHU Lin-feng(Department of Obstetrical,Beijing Pinggu Hospital,Beijing 101200,China)

机构地区：[1]北京市平谷区医院产科,北京101200

出　　处：《川北医学院学报》2023年第8期1078-1081,共4页Journal of North Sichuan Medical College

基　　金：北京市平谷区医院院内科研项目(Pgyy2020-01)。

摘　　要：目的:探究血清胎盘生长因子(PLGF)、胰岛素生长因子-1(IGF-1)及可溶性血管内皮生长因子受体-1(sFlt-1)水平对子痫前期(PE)孕妇妊娠结局的预测价值。方法:选取110例PE孕妇为研究对象(PE组),根据病情严重程度、妊娠结局将孕妇分为4个亚组:轻度PE组(n=47)、重度PE组(n=63);妊娠结局不良组(n=72)、妊娠结局良好组(n=38)。另选取100例同期健康孕妇作为对照组。检测各组孕妇的一般资料及血清PLGF、IGF-1、sFLT-1水平,采用Logistic分析影响子痫前期孕妇妊娠结局的因素,采用受试者工作特征曲线(ROC)分析血清指标对妊娠结局的预测价值。结果:各组孕妇血清PLGF、IGF-1水平比较:对照组>轻度PE组>重度PE组;对照组>妊娠结局良好组>妊娠结局不良组,差异均有统计学意义(P<0.05)。血清sFlt-1浓度比较:对照组<轻度PE<重度PE组;对照组<妊娠结局良好组<妊娠结局不良组,差异均有统计学意义(P<0.05)。妊娠结局不良和妊娠结局良好组孕妇年龄、孕周、孕次及产次比较,差异均无统计学意义(P>0.05);Logistic回归分析显示,血清PLGF、IGF-1及sFLT-1均为PE患者妊娠结局的影响因素(P<0.05);ROC结果显示,PLGF、IGF-1及sFLT-1血清浓度均具有预测妊娠结局的应用价值,且三者联合预测的AUC(0.870)最高(P<0.05),敏感度、特异度分别为84.21%、77.78%。结论:PE孕妇血清中的PLGF、IGF-1和sFLT-1水平与疾病的严重程度和预后密切相关,血清PLGF和IGF-1水平越低,sFLT-1浓度越高,孕妇的疾病可能越严重,不良的妊娠结局可能性也越高。Objective:To explore the predictive value of serum placental growth factor(PLGF),insulin growth factor-1(IGF-1),and soluble vascular endothelial growth factor receptor-1(sFlt-1)expression levels on pregnancy outcomes in preeclampsia(PE)pregnant women.Methods:A total of 110 pregnant women with PE were classified as the PE group,and were divided into four subgroups based on their severity and pregnancy outcome(47 cases in the mild PE group,63 cases in the severe PE group,72 cases in the poor pregnancy outcome group,and 38 cases in the good pregnancy outcome group).Another 100 healthy pregnant women of the same period were selected as the control group.The expressions of serum PLGF,IGF-1 and sFLT-1 in general data of all pregnant women were detected.Logistic analysis was used to analyze the factors that affect the pregnancy outcome of preeclampsia pregnant women,and the predictive value of serum indicators on pregnancy outcome was analyzed using the receiver operating characteristic curve(ROC).Results:Comparison of serum PLGF and IGF-1 levels among pregnant women in each group:control group>mild PE>severe PE,control group>good pregnancy outcome group>poor pregnancy outcome group,the differences were statistically significant(P<0.05).Serum sFlt-1 concentration comparison:control group<mild PE<severe PE group,control group<good pregnancy outcome group<bad pregnancy outcome group,the differences were statistically significant(P<0.05).There were no differences in age,gestational week,gestational number and delivery number between the poor pregnancy outcome group and the good pregnancy outcome group(P>0.05).Logistic analysis showed that serum PLGF,IGF-1 and sFLT-1 were all influencing factors of pregnancy outcome in PE patients(P<0.05).ROC analysis showed that PLGF,IGF-1 and sFLT-1 serum concentrations all had certain application value in predicting pregnancy outcome,and the combined prediction of the three serum concentrations was the highest(0.870,P<0.05),and the sensitivity and specificity were 84.21%and 77.78%,respec

关 键 词：子痫前期 胎盘生长因子 胰岛素生长因子-1 可溶性血管内皮生长因子受体-1 妊娠结局 预测价值 

分 类 号：R714.24[医药卫生—妇产科学]