Genetic variants in the ADD1 and GNB3 genes and bloodpressure response to potassium supplementation  

作　　者：Dai-Hai YU De-Pei LIU Lai-Yuan WANG Jing CHEN Cashell E.JAQUISH Dabeeru C.RAO James E.HIXSON Jian-Feng HUANG Chung-Shiuan CHEN Charles GU Ji-Chun CHEN Jie CAO Shu-Feng CHEN Paul K.WHELTON Jiang HE Dong-Feng GU 

机构地区：[1]Department of Evidence-based Medicine and Population Genetics,Cardiovascular Institute and Fu Wai Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China [2]Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100005,China [3]Chinese National Human Genome Center at Beijing,Beijing 100176,China [4]Department of Epidemiology,Tulane University School of Public Health and Tropical Medicine,New Orleans,LA 70112,USA [5]Department of Medicine,Tulane University School of Medicine,New Orleans,LA 70112,USA [6]National Heart,Lung,and Blood Institute,National Institute of Health,Bethesda,MD 20892,USA [7]Washington University in St.Louis School of Medicine,St.Louis,MO 63110,USA [8]University of Texas School of Public Health,Houston,TX 77030,USA [9]Loyola University Medical Center,Maywood,IL 60153,USA

出　　处：《Frontiers of Medicine》2010年第1期59-66,共8页医学前沿（英文版）

基　　金：supported by research grants(Nos.U01HL072507,R01HL087263,and R01HL090682)from the National Heart,Lung;Blood Institute,National Institutes of Health,Bethesda,MD.Upsher-Smith Laboratories,Maple Grove,MN,has provided Klor-Con M20 potassium tablets for the GenSalt study.

摘　　要：Dietary potassium-supplementation has been associated with a decreased risk of hypertension and other cardiovascular outcomes.However,blood pressure(BP)responses to potassium supplementation vary among individuals.This study was designed to examine the association between 12 single nucleotide polymorphisms(SNPs)in the adducin 1 alpha(ADD1)and guanine nucleotide binding protein(G protein)beta polypeptide 3(GNB3)genes and systolic BP(SBP),diastolic BP(DBP),and mean arterial pressure(MAP)responses to potassium-supplementation.We conducted a 7-day high-sodium intervention(307.8 mmol sodium/day)followed by a 7-day high-sodium with potassium-supplementation(60 mmol potassium/day)among 1906 Han Chinese participants from rural north China.BP measurements were obtained at the end of each intervention period using a random-zero sphygmomanometer.We identified significant associations between ADD1 variant rs17833172 and SBP,DBP,and MAP responses to potassium-supplementation(all P<0.0001)that remained significant after adjustment for multiple comparisons.In participants that were heterozygous or homozygous for the G allele of this marker,SBP,DBP,and MAP response to potassium-supplementation were–3.52(–3.82,–3.21),–1.41(–1.66,–1.15)and–2.12(–2.37,–1.87),respectively,as compared to the corresponding responses of 1.99(0.25,3.73),–0.65(–0.10,–0.21),and–0.23(–0.37,0.83),respectively,for those who were homozygous for A allele.In addition,participants with at least one copy of the G allele of rs12503220 of the ADD1 gene had significantly increased DBP and MAP response to potassium-supplementation(P=0.0041 and 0.01,respectively),which was also significant after correction for multiple testing.DBP and MAP responses to potassiumsupplementation were–1.36(–1.63,–1.10)and–2.07(–2.32,–1.82)for those with at least G allele compared to corresponding responses of 0.86(–0.68,2.40)and–0.45(–1.74,0.84)for those who were homozygous for A allele.In summary,our study identified novel associations bet

关 键 词：blood pressure genetics polymorphism dietary potassium potassium sensitivity adducin 1 alpha(ADD1) guanine nucleotide binding protein beta polypeptide 3(GNB3) 

分 类 号：R61[医药卫生—外科学]