CD 163基因在猪繁殖与呼吸综合征抗病育种中的研究进展  

Research Progress of CD 163 Gene and Disease-Resistant Breeding on Porcine Reproductive and Respiratory Syndrome

作　　者：王慧 冯保亮 吴丹 向光明 王楠[1] 牟玉莲[1] 李奎[1,3] 刘志国 WANG Hui;FENG Baoliang;WU Dan;XIANG Guangming;WANG Nan;MU Yulian;LI Kui;LIU Zhiguo(Institute of Animal Sciences,Chinese Academy of Agricultural Sciences,Beijing 100193,China;Tianjin Ninghe yuan Swine Breeding Pig Farm Co.,Ltd.,Tianjin 301504,China;Agricultural Genomics Institute at Shenzhen,Chinese Academy of Agricultural Sciences,Shenzhen 518120,China)

机构地区：[1]中国农业科学院北京畜牧兽医研究所,北京100193 [2]天津市宁河原种猪场有限责任公司,天津301504 [3]中国农业科学院农业基因组研究所,深圳518120

出　　处：《畜牧兽医学报》2023年第8期3127-3138,共12页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：科技创新2030-重大项目(2022ZD040200401);深圳市科技计划项目(CJGJZD20210408092402006);中国农业科学院科技创新工程(ASTIP-IAS05)。

摘　　要：清道夫受体超家族是一个结构相关的跨膜糖蛋白家族,其特征是包含高度保守的富含半胱氨酸的清道夫受体(scavenger receptor cysteine-rich,SRCR)结构域。CD163蛋白为清道夫受体超家族的B型成员,包含9个SRCR结构域,富含半胱氨酸序列,主要在单核细胞和巨噬细胞中表达。研究发现CD163蛋白是猪繁殖与呼吸综合征病毒(porcine reproductive and respiratory syndrome virus,PRRSV)的必需受体,参与PRRSV的脱衣壳过程,而且可能参与非洲猪瘟病毒(African swine fever virus,ASFV)的吸附和内化过程。除此之外,CD163蛋白还在免疫生理等多种重要的生物学过程中发挥不可替代的作用。本综述就CD163分子的基本信息、相关生理功能及其在猪繁殖与呼吸综合征抗病育种中的研究进展做综合介绍,为抗病动物新品种培育提供参考。Scavenger receptor superfamily is a structurally related transmembrane glycoprotein family.Its characteristic component is a highly conserved scavenger receptor cysteine-rich(SRCR)domain.CD163,which is a type B scavenger receptor and has 9 SRCR domains,is highly expressed in monocyte and macrophages.It was reported that CD163 is an essential receptor of porcine reproductive and respiratory syndrome virus(PRRSV),involved in the uncoating process of PRRSV and possibly participated in the attachment and internalization of African swine fever virus(ASFV).In addition,CD163 plays an irreplaceable role in many important biological processes.This review introduces the basic information,physiological functions and research progress of CD163 in pig disease-resistant breeding on PRRSV,providing reference for disease-resistant animal breeding.

关 键 词：清道夫受体 CD163 生理生化功能 猪繁殖与呼吸综合征病毒 非洲猪瘟病毒 

分 类 号：S828.2[农业科学—畜牧学]