血清脂肪型脂肪酸结合蛋白与稳定性冠心病主动脉硬化程度的相关性研究  

Correlation between serum A-FABP and degree of aortic stiffness in SCAD

作　　者：岳晓荷 莫宏强 赵莲 盛国玉 Yue Xiaohe;Mo Hongqiang;Zhao Lian;Sheng Guoyu(Department of Clinical Laboratory,Dongfang People's Hospital,Dongfang 572600,Hainan Province,China)

机构地区：[1]东方市人民医院检验科,572600 [2]东方市人民医院心内科,572600 [3]海南医学院第一附属医院检验科

出　　处：《中华老年心脑血管病杂志》2023年第8期837-841,共5页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：海南省卫生计生行业科研项目(18A200070)。

摘　　要：目的 分析血清脂肪型脂肪酸结合蛋白(A-FABP)与稳定性冠心病(SCAD)动脉硬化程度的关系。方法 前瞻性选择2016年10月至2021年10月东方市人民医院心内科因慢性冠心病和突发胸痛首次接受冠状动脉造影的疑似老年冠心病患者365例,其中SCAD组241例,对照组124例。采用酶联免疫吸附法检测血清A-FABP水平。采用颈-股动脉脉搏波速度(cfPWV)分析SCAD患者动脉硬化程度。结果 SCAD组血清A-FABP水平明显高于对照组[7.19(4.09,14.93)μg/L vs 1.78(1.22,3.37)μg/L,P<0.01]。ROC曲线分析显示,血清A-FABP水平诊断SCAD的曲线下面积为0.856。血清A-FABP≥5.95μg/L是SCAD患者发生主动脉僵硬的独立临床因素(P<0.01)。Spearman秩相关分析显示,SCAD患者血清A-FABP水平与cfPWV、基质金属蛋白酶9、白细胞介素1β、TG、SYNTAX评分呈正相关,与HDL-C呈负相关(P<0.01)。血清A-FABP水平是SCAD患者SYNTAX评分中重度的独立危险因素(P<0.05,P<0.01)。结论 SCAD患者血清A-FABP水平普遍升高,高血清A-FABP水平与SCAD患者主动脉僵硬度增加独立相关,且预示着SCAD患者预后不良。Objective To analyze the relationship between the serum level of adipocyte fatty acid-binding protein(A-FABP)and the degree of aortic stiffness in patients with stable coronary artery disease(SCAD).Methods From October 2016 to October 2021,365 suspected elderly patients with coronary heart disease who underwent coronary angiography for the first time in the Department of Cardiology of Dongfang People's Hospital due to chronic coronary heart disease and sudden chest pain were prospectively enrolled,and 241 of them were assigned into the SCAD group and 124 into the control group.Serum A-FABP level was determined by ELISA.cfPWV was used to analyze the severity of atherosclerosis in the SCAD patients.Results The serum A-FABP level was significantly higher in the SCAD group than the control group[7.19(4.09,14.93)μg/L vs 1.78(1.22,3.37)μg/L,P<0.01].ROC curve analysis showed that the AUC value of serum A-FABP level for the diagnosis of SCAD was 0.856.The serum A-FABP≥5.95μg/L was an independent clinical factor of aortic stiffness in SCAD patients(P<0.01).Spearman rank correlation analysis indicated that the serum A-FABP level was positively correlated with cfPWV,MMP-9,IL-1β,TG and SYNTAX score,and negatively with HDL-C(P<0.01).Serum A-FABP level was an independent risk factor for moderate and high SYNTAX score of SCAD patients(P<0.05,P<0.01).Conclusion Serum A-FABP level is generally increased in SCAD patients.High serum A-FABP level is independently related to the increase of aortic stiffness in these patients,indicating poor prognosis.

关 键 词：冠心病 脂肪酸结合蛋白质类 动脉硬化 血管造影术 颈-股动脉脉搏波速度 SYNTAX评分 

分 类 号：R541.4[医药卫生—心血管疾病]