小儿豉翘清热颗粒联合帕拉米韦治疗儿童流行性感冒疗效观察及对CRP、IL-6、TNF-a、血常规的影响  

Therapeutic Effect of Xiaoer Chiqiao Qingre Granule Combined with Pramivir on Influenza in Children and Its Effect on CRP,IL-6,TNF-αand Blood Routine

作　　者：吴晓芬 侯睿 Wu Xiao-fen;Hou Rui(Xigu District People's Hospital of Lanzhou City,Department of Paediatrics,Lanzhou 730060,Gansu Province,China;Lanzhou City Xigu District Hospital of Traditional Chinese Medicine department of paediatrics,Lanzhou 730060,Gansu Province,China)

机构地区：[1]兰州市西固区人民医院儿科,甘肃兰州730060 [2]兰州市西固区中医医院儿科,甘肃兰州730060

出　　处：《罕少疾病杂志》2023年第8期44-45,57,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨儿童流行性感冒中,小儿豉翘清热颗粒联合帕拉米韦的疗效及对CRP、白介素6(IL-6)、TNF-α、血常规的影响。方法选取2020年5月至2022年2月兰州市西固区人民医院儿科收治的96例流行性感冒患儿,随机分为两组,其中48例患儿接受帕拉米韦治疗为对照组,48例患儿接受小儿豉翘清热颗粒联合帕拉米韦治疗为观察组。比较两组患儿疗效、症状消失时间、痊愈时间、治疗前后两组患儿血清C反应蛋白(CRP)、IL-6、肿瘤坏死因子-α(TNF-α)水平及血常规相关指标变化及不良反应发生率。结果观察组治疗总有效率(97.92%),高于对照组(83.33%)(P值<0.05);观察组发热、咳嗽、咽痛等症状消失时间和痊愈时间均低于对照组,差异有统计学意义(P<0.05);治疗后,两组患儿白细胞总数、淋巴细胞百分比均低于治疗前,中性粒细胞百分比、红细胞、血小板均高于治疗前,差异有统计学意义(P值均<0.05),两组患儿治疗后白细胞总数、中性粒细胞百分比、淋巴细胞百分比对比,差异有统计学意义(P值均<0.05);两组患儿不良反应发生情况比较(10.42%vs14.58%),差异无统计学意义(χ^(2)=0.381,P=0.537)。结论在儿童流行性感冒的治疗中,小儿豉翘清热颗粒联合帕拉米韦能有效缓解临床症状,降低血清炎性因子CRP、IL-6、TNF-α水平,使血常规相关指标恢复正常,疗效显著,值得被广泛推广。Objective To investigate the efficacy of Xiaoer Chiqiao Qingre Granule Combined with pramivir in the treatment of children with influenza and its effect on C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)and blood routine.Methods 96 influenza patients treated in pediatrics of Lanzhou XiGu District People's Hospital from May 2020 to February 2022 were selected.They were randomly divided into two groups,of which 48 patients were treated with pramivir as the control group and 48 patients were treated with Xiaoer Chiqiao Qingre Granule Combined with pramivir as the observation group.The curative effect,symptom disappearance time,recovery time,CRP,IL-6,TNF-α,Changes of blood level and blood routine related indexes and incidence of adverse reactions.of the two groups were compared before and after treatment.Results The total effective rate of the observation group(97.92%)was higher than that of the control group(83.33%)(P<0.05).The fever,cough,sore throat,nasal congestion and recovery time of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05).After treatment,the total number of leukocytes and percentage of lymphocytes in the two groups were lower than those before treatment,and the percentage of neutrophils,erythrocytes and platelets were higher than those before treatment,the difference was statistically significant(P<0.05).After treatment,the total number of leukocytes,percentage of neutrophils and percentage of lymphocytes in the two groups were compared,the difference was statistically significant(P<0.05),There was no significant difference(P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups(10.42%vs 14.58%)(χ^(2)=0.381,P=0.537).Conclusion In the treatment of influenza in children,Xiaoer Chiqiao Qingre Granule Combined with pramivir can effectively alleviate clinical symptoms and reduce serum inflammatory factors CRP,IL-6 and TNF-αLevel,so that the blood routi

关 键 词：小儿豉翘清热颗粒 帕拉米韦 流行性感冒 CRP、白介素6、TNF-α、血常规 

分 类 号：R373.13[医药卫生—病原生物学]