小儿原发性肾病综合征患儿血浆蛋白Z、凝血因子Ⅷ活性的检验研究  

Study on the Activity of Plasma Protein Z and Coagulation FactorⅧin Children with Primary Nephrotic Syndrome

作　　者：李晓蕾[1] 聂曼杰 Li Xiao-lei;Nie Man-jie(Children's Hospital Affiliated to Zhengzhou University,Henan Children's Hospital,Zhengzhou Children's Hospital Laboratory Department,Zhengzhou 450000,Henan Province,China)

机构地区：[1]郑州大学附属儿童医院河南省儿童医院郑州儿童医院检验科,河南郑州450000

出　　处：《罕少疾病杂志》2023年第8期61-62,共2页Journal of Rare and Uncommon Diseases

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20210687)。

摘　　要：目的分析原发性肾病综合征患儿的检验指标,探讨血浆蛋白Z、凝血因子Ⅷ活性水平的检验意义。方法将本院在2020年10月至2021年10月之间收治的原发性肾病综合征患儿中选取40例作为研究组。保持均衡性抽取同一时间段内的40名健康儿童(对照组),均为健康体检者。对所有儿童检测,纳入血浆蛋白Z水平、凝血因子Ⅷ活性等指标,对不同组别和不同发病阶段患儿体内该水平的差异。结果研究组的血浆蛋白Z与对照组对比可见差异,SPSS分析可见低于对照组,血浆蛋白Z在急性期的含量明显低于恢复期(P<0.05)。研究组凝血因子Ⅷ含量统计学分析差异明显,SPSS分析可见其水平高于对照组,急性期的含量远高于恢复期(P<0.05),均具有统计学意义。结论原发性肾病综合征儿童检验指标可能发生变化,其中以血浆蛋白Z含量变化明显,同时凝血因子Ⅷ活性发生改变。检测上述指标能够分析疾病状态,可作为疾病诊疗和预后分析的依据,具有重要临床研究价值。Objective To analyze the test indexes of children with primary nephrotic syndrome and explore the significance of plasma protein Z and coagulation factor VIII activity levels.Methods 40 children with primary nephrotic syndrome admitted in our hospital from October 2020 to October 2021 were selected as the research group.40 healthy children(control group)in the same time period were selected in a balanced way,all of whom were healthy physical examinees.All children were tested,including plasma protein Z level,coagulation factor VIII activity and other indicators,and the differences of this level in different groups and different stages of illness were analyzed.Results The plasma protein Z in the study group was significantly lower than that in the control group by SPSS analysis,and the content of plasma protein Z in the acute phase was significantly lower than that in the recovery period(P<0.05).There was significant difference in the content of coagulation factor VIII between the study group and the control group by SPSS analysis,and the content in acute phase was much higher than that in recovery period(P<0.05),which was statistically significant.Conclusion The test indexes of children with primary nephrotic syndrome may change,especially the content of plasma protein Z and the activity of coagulation factor VIII.Detection of the above indicators can analyze the disease state,and can be used as the basis for diagnosis,treatment and prognosis analysis of diseases,which has important clinical research value.

关 键 词：小儿原发性肾病综合征 血浆蛋白Z 凝血因子Ⅷ 临床检验 

分 类 号：R322.61[医药卫生—人体解剖和组织胚胎学]