超声心动图联合血清NT-proBNP、hs-CRP检测在子痫前期患者中的应用价值  

Application value of echocardiography combined with serum NT-proBNP and hs-CRP in patients with preeclampsia

作　　者：刘淼 卢薇薇[1] LIU Miao;LU Weiwei(Ultrasound Department,Shangqiu First People's Hospital,Shangqiu,Henan 476100,China)

机构地区：[1]商丘市第一人民医院超声科,河南商丘476100

出　　处：《中国医学工程》2023年第8期92-96,共5页China Medical Engineering

基　　金：河南省医学科技攻关计划项目(LHGJ20210990)。

摘　　要：目的探究超声心动图联合血清N末端脑钠肽前体(NT-proBNP)、超敏C反应蛋白(hs-CRP)检测在子痫前期患者中的应用价值。方法选取2020年2月至2021年2月商丘市第一人民医院收治的82例子痫前期患者的临床资料进行回顾性分析,其中重度子痫前期患者41例,设为重度组,轻度子痫前期患者41例,设为轻度组。选取同期来院健康体检的健康孕妇的临床资料共41例,设为健康组。对比三组研究对象的超声心动图参数及血清NT-proBNP、hs-CRP水平。结果三组研究对象的LVEF水平组间两两比较,差异有统计学意义(P<0.05)。轻度组、重度组的A值高于健康组(P<0.05),但轻度组、重度组间A值比较,差异无统计学意义(P>0.05)。轻度组、重度组的E/A值低于健康组(P<0.05),但轻度组、重度组间E/A值比较,差异无统计学意义(P>0.05)。三组研究对象的IVSd水平组间两两比较,差异均有统计学意义(P<0.05)。轻度组、重度组的LVPWd、LVESd、LVEDd水平均高于健康组(P<0.05),但轻度组的LVPWd、LVESd、LVEDd水平与重度组比较,差异无统计学意义(P>0.05)。三组研究对象血清hs-CRP、NT-proBNP水平组间两两比较,差异均有统计学意义(P<0.05)。LVEF水平与hs-CRP、NT-proBNP均呈负相关(P<0.05)。IVSd水平与hs-CRP、NT-proBNP均呈正相关(P<0.05)。受试者操作特征(ROC)曲线下面积分析可知,hs-CRP、NT-proBNP、LVEF、IVSd联合诊断优于四项指标单独诊断(P<0.05)。结论超声心动图联合血清NT-proBNP、hs-CRP水平检测在子痫前期患者病情严重程度诊断中具有较好的价值。【Objective】To explore the application value of echocardiography combined with serum NT-proBNP and hs-CRP in patients with preeclampsia.【Methods】The clinical data of 82 patients with preeclampsia admitted to our hospital from February 2020 to February 2021 were retrospectively analyzed.Among them,41 patients with severe preeclampsia were set as severe group,and 41 patients with mild preeclampsia were set as mild group.The clinical data of 41 healthy pregnant women who came to our hospital for health examination at the same time were selected as the healthy group.The echocardiographic parameters and serum NT-proBNP,hs-CRP levels of the three groups were compared.【Results】LVEF levels of the three groups were significantly different between the two groups(P<0.05).The A value of mild group and severe group was significantly higher than that of healthy group(P<0.05),but there was no significant difference between mild group and severe group(P>0.05).The E/A value of mild group and severe group was significantly lower than that of healthy group(P<0.05),but there was no significant difference between mild group and severe group(P>0.05).The IVSd levels of the three groups were significantly different between the two groups(P<0.05).LVPWd,LVESd and LVEDd levels in mild group and severe group were significantly higher than those in healthy group(P<0.05),but the LVPWd,LVESd and LVEDd levels in mild group were not significantly different from those in severe group(P>0.05).The levels of hs-CRP and NT-proBNP in serum of the three groups were significantly different(P<0.05).LVEF level was negatively correlated with hs-CRP and NT-proBNP(P<0.05).IVSd level was positively correlated with hs-CRP and NT-proBNP(P<0.05).The area analysis under the ROC curve showed that the combined diagnosis of hs-CRP,NT-proBNP,LVEF and IVSd was significantly better than the single diagnosis of the four indicators(P<0.05).【Conclusion】Echocardiography combined with the detection of serum NT-proBNP and hs-CRP levels has a good value in the

关 键 词：超敏C反应蛋白 N末端脑钠肽前体 超声心动图 子痫前期 应用价值 

分 类 号：R714.252[医药卫生—妇产科学]