中性粒细胞胞外陷阱在慢性气道炎症性疾病中作用的研究进展  

Advances in the role of neutrophil extracellular traps in chronic airway inflammatory diseases

作　　者：刘明远 刘艳梅 李登珺 谈华栋 王迎难 LIU Mingyuan;LIU Yanmei;LI Dengjun;TAN Huadong;WANG Yingnan(Pulmonary and Critical Care Medicine,The First College of Clinical Medical Science,China Three Gorges University,Yichang 443000,China)

机构地区：[1]三峡大学第一临床医学院呼吸与危重症医学科,湖北宜昌443000

出　　处：《老年医学研究》2023年第4期58-63,共6页Geriatrics Research

摘　　要：中性粒细胞胞外陷阱(NETs)是由DNA和抗菌蛋白组成的大型网状结构,能够结合病原体,防止微生物传播并降解细菌毒力因子。然而NETs组成蛋白如蛋白酶、抗菌蛋白、组蛋白和DNA过度释放也会导致组织损伤、黏膜纤毛清除受损和炎症增加。许多研究已将气道NETs形成与慢性气道炎症性疾病中疾病严重程度增加、急性加重次数增加和整体疾病恶化结局联系起来。本文将综述NETs在肺囊性纤维化、慢性阻塞性肺疾病、哮喘和支气管扩张慢性气道炎症性疾病中的作用。Neutrophil extracellular traps(NETs)are large reticular structure composed of DNA and antibacterial pro-teins,which can bind pathogens,prevent microbial transmission and degrade bacterial virulence factors.However,exces-sive release of NETs constituent proteins such as proteases,antibacterial proteins,histones and DNA can also lead to tis-sue damage,impaired mucociliary clearance and increased inflammation.Many studies have linked the formation of air-way NETs with an increase in disease severity,acute exacerbation frequency,and overall disease progression in chronic airway inflammatory diseases.This article reviews the role of NETs in pulmonary cystic fibrosis,chronic obstructive pulmo-nary disease,asthma and bronchiectasis.

关 键 词：中性粒细胞 中性粒细胞外陷阱 慢性气道炎症 肺囊性纤维化 慢性阻塞性肺疾病 哮喘 支气管扩张 

分 类 号：R563[医药卫生—呼吸系统]