Anti-hyperglycemic effect of the polysaccharide fraction isolated from mactra veneriformis  

作　　者：Lingchong WANG Hao WU Nian CHANG Kun ZHANG 

机构地区：[1]College of Pharmaceutical Science,Nanjing University of Chinese Medicine,Nanjing 210046,China [2]Research Center of Marine Drug in Jiangsu Province,Nanjing 210046,China

出　　处：《Frontiers of Chemical Science and Engineering》2011年第2期238-244,共7页化学科学与工程前沿（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant No.30900293);the R&D Special Fund for Public Welfare Industry from State Ocean Administration of China(No.200709005)。

摘　　要：Total macromolecule extract was obtained from the soft body of Mactra veneriformis by the coupling techniques of decoction and alcohol precipitation.The extract was deproteinized with an ion exchange column,and resulted in the purifying of the crude polysaccharide fraction.It was found by chemical analysis that the crude polysaccharide part is composed of abundant polysacchar-ides(>95%)and few proteins(<1%).Furthermore,only one type of monosaccharide,glucose,was detected from its hydrolytes by thin-layer chromatography,indicating that the polysaccharides might be analogs of glucosan.The anti-hyperglycemia effects of the crude polysaccharide part were preliminarily investigated using several pharmacolo-gical methods in normal and diabetic mice.Animal experimental results showed that the crude polysaccharide fraction exhibited proper glycemia inhibition activity,and 300 mg/kg-weight dose has the optimal effect among all the studied doses.It is concluded that the crude polysaccharide fraction can be explored as a novel health product that possesses potential as an anti-hyperglycemic agent.

关 键 词：ANTI-HYPERGLYCEMIA Mactra veneriformis POLYSACCHARIDE monosaccharide composition oral glucose tolerance test 

分 类 号：O62[理学—有机化学]