老年重叠综合征患者维生素D水平与焦虑、抑郁及BODE指数的相关性研究  

Correlation of Vitamin D Level with Anxiety,Depression,and BODE Index in Elderly Patients with Overlapping Syndrome

作　　者：欧华静 万首伟 王瑞 王静[1] OU Huajing;WAN Shouwei;WANG Rui(The Second Department of Respiratory Medicine,the First Affiiated Hospital of Medical College of Shihezi University,Shihezi City,Xinjiang 832000)

机构地区：[1]石河子大学医学院第一附属医院呼吸二科,新疆石河子市832000 [2]石河子大学医学院 [3]石河子市人民医院胸外科

出　　处：《医学理论与实践》2023年第16期2704-2707,共4页The Journal of Medical Theory and Practice

摘　　要：目的:观察老年慢性阻塞性肺疾病合并阻塞性睡眠呼吸暂停低通气综合征(重叠综合征,OS)患者维生素D水平的变化,并探讨其与焦虑、抑郁、BODE指数的相关性。方法:选取2018年5月—2020年10月于石河子大学医学院第一附属医院住院的单纯老年慢性阻塞性肺疾病患者48例(COPD组),老年OS患者58例(OS组)。所有纳入患者均行肺功能及多导睡眠检测(PSG)检查,并记录FEV_(1)/FVC、睡眠呼吸紊乱指数(AHI);采用汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、BODE指数评估患者焦虑、抑郁及生活质量情况;ELISA法检测外周血血清维生素D水平,并把OS组分为维生素D水平正常(OS1)组、维生素D水平不足(OS2)组、维生素D水平缺乏(OS3)组。结果:OS组血清维生素D水平明显低于COPD组,HAMA评分、HAMD评分、BODE指数评分明显高于COPD组(P均<0.05);与OS2组、OS1组相比,OS3组HAMA评分、HAMD评分、BODE指数明显较高,且OS2组明显高于OS1组(P<0.05);在OS组中,维生素D水平与HAMA评分、HAMD评分、BODE指数呈负相关。结论:与单纯COPD患者相比,OS患者维生素D水平更低、生活质量更差,更容易发生焦虑、抑郁;对于OS患者,维生素D水平与焦虑、抑郁程度相关,维生素D水平越低者生活质量越差。Objective:To observe the changes of vitamin D level in elderly patients with chronic obstructive pulmonary disease(COPD)complicated with obstructive sleep apnea hypopnea syndrome(overlap syndrome,OS),and to explore its correlation with anxiety,depression and BODE index.Methods:A total of 48 elderly patients with chronic obstructive pulmonary disease(COPD group)and 58 elderly patients with OS(OS group)hospitalized in the First Affiliated Hospital of Medical College of Shihezi University from May 2018 to October 2020 were selected.All patients underwent pulmonary function and polysomnography(PSG)examination,and FEV_1/FVC and sleep-disordered breathing index(AHI)were recorded.Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD)and BODE index were used to evaluate the patients'anxiety,depression and quality of life.The levels of vitamin D in peripheral blood were detected by ELISA,and the OS group were divided into normal vitamin D level(OS1)group,insufficient vitamin D level(OS2)group and deficient vitamin D level(OS3)group.Results:The serum vitamin D level in OS group was significantly lower than that in COPD group,and the HAMA score,HAMD score and BODE index score were visibly higher than those in COPD group(all P<0.05).Compared with OS2 group and OS1 group,HAMA score,HAMD score and BODE index in OS3 group were obviously higher,and OS2 group was distinctly higher than OS1 group(P<0.05).In OS group,vitamin D level was negatively correlated with HAMA score,HAMD score and BODE index.Conclusion:Compared with COPD patients alone,OS patients have lower vitamin D level,worse quality of life,and more likely to suffer from anxiety and depression.For OS patients,vitamin D level is associated with anxiety and depression,the lower the vitamin D level,the worse the quality of life.

关 键 词：重叠综合征 维生素D 焦虑 抑郁 BODE指数 

分 类 号：R563[医药卫生—呼吸系统]